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Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.
This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.
Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled “Killing Cancer: Discovery and Selection of New Target Molecules”. These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.
This book provides postgraduate trainees with 50 real clinical cardiology cases. Divided into fourteen sections, several cases are presented under each category covering various disorders of the cardiac system, including congenital heart diseases, aortic valve diseases, pulmonary diseases, ECG abnormalities, cardiac arrhythmias, coronary artery disease and much more. Beginning with a brief history and findings based on physical examination, each case then includes analytical discussion on bedside investigations and proposals for treatment. Authored by a recognised expert in the field, this practical book is highly illustrated with echocardiographic, radiographic and electrocardiographic data. Key points Presents 50 real clinical cardiology cases Covers numerous disorders of the cardiac system Authored by recognised cardiologist Includes more than 217 images, illustrations and tables