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New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Advances in Architecture, Engineering and Technology
This book examines a range of subjects with a specific focus on architectural and technological advancements. Architecture is the constant innovation in designing for high efficiency in the performance of buildings, in terms of planning, construction and energy, while maintaining creativity in its form. Moreover, the field of architecture goes hand in hand with that of technology. Nowadays, engineering technology has to cope with the rapid industrialization and urbanization seen in most countries. Furthermore, creative design and construction practices are challenging tasks to the architects and engineers to meet the ever-growing demands of society. Therefore, this book on "Advances in Engineering Science and Architectural Design" is provided to cover a wide range of topics in architecture, engineering, and technology.
International RILEM Conference on Synergising Expertise towards Sustainability and Robustness of Cement-based Materials and Concrete Structures
This book highlights the latest advances, innovations, and applications in cement-based materials (CBM) and concrete structures, as presented by leading international researchers and engineers at the International RILEM Conference on synergizing expertise toward sustainability and robustness of CBM and concrete structures (SynerCrete), held in Milos Island, Greece, on June 14-16, 2023. The aim of the conference was to discuss and arouse progress in research, development, and application of CBM and structural concrete through combination of expertise from distinct fields of knowledge, such as performance-based design, 3D modeling for analysis/design, building information modeling, and even ro...
Shot-Earth for an Eco-friendly and Human-Comfortable Construction Industry
This book presents an innovative and environmentally friendly type of excavated earth-based building material, called Shot-Earth. The use of a common excavated earth as a construction material (both for structural and non-structural applications) has many important advantages, the main one being that the soil can be used as a zero kilo and zero cost material, being used in the same place where it is excavated. This volume collects the main results obtained by the research units in the FIRS2019-00245 research project, funded by the Italian Ministry of Research (MUR) and dedicated to the study of Shot-Earth materials. Many of the exposed contributions concern the optimization of the mixture an...
Urban Resilience, Livability, and Climate Adaptation
This book explores urban environments and their impact on resilience, livability, climate adaptation, health, and societal well-being. It provides interdisciplinary insights for fostering resilient, livable, and sustainable cities prioritizing well-being and quality of life for all residents. The book covers various topics and discusses innovative approaches for incorporating nature into urban planning. It also examines the relationships between diet diversity, food environments, and transportation systems. Spatial analysis of noise contour maps based on traffic speed is conducted, along with an assessment of the impact of office environments on productivity. The book explores the influence ...
Mitigation and Adaptation of Urban Overheating
Provides a fully organized, comprehensive, and holistic analysis of the impact of urban overheating, mitigation, and adaptation on energy, health, environmental quality, survivability, quality of life, and economy Mitigation and Adaptation of Urban Overheating aims to analyze and present all existing relative studies to investigate the global magnitude and characteristics of the ambient temperature drop and the reduction of the heat burden resulting from modified climate conditions due to the implementation of urban mitigation and adaptation technologies and policies. This book will discuss urban overheating, urban heat mitigation, governance, anthropogenic heat emissions, adaptation and ada...
Computational Science and Its Applications – ICCSA 2022 Workshops
The eight-volume set LNCS 13375 – 13382 constitutes the proceedings of the 22nd International Conference on Computational Science and Its Applications, ICCSA 2022, which was held in Malaga, Spain during July 4 – 7, 2022. The first two volumes contain the proceedings from ICCSA 2022, which are the 57 full and 24 short papers presented in these books were carefully reviewed and selected from 279 submissions. The other six volumes present the workshop proceedings, containing 285 papers out of 815 submissions. These six volumes includes the proceedings of the following workshops: Advances in Artificial Intelligence Learning Technologies: Blended Learning, STEM, Computational Thinking and...
Urban Microclimate Modelling for Comfort and Energy Studies
This book discusses urban microclimate and heat-related risks in urban areas, brought on by the combination of global climate change effects and local modification of climate determined by extensive urbanization such as the ‘Urban heat island’ phenomenon. This matter is relevant to almost all urbanized areas in the world, where the increase of urban population and air temperature is expected to endanger both the overall health of the population and the energy supply for the functioning of urban systems. The book details the inter-relationship between urban morphology, microclimate and building energy performance and presents a multidisciplinary approach that brings together Urban Climatology, Engineering and Architectural knowledge to support the development of reliable models and tools for research and practice. This book is a useful tool for architects and building energy modelers, urban planners and geographers who need a practical guide to realize basic urban microclimate simulation for use in both academic research and planning practice.
