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Chromogranins: from Cell Biology to Physiology and Biomedicine
The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.
Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease
The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two level...
New Research on Signal Transduction
In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. In such cases the chain of steps is referred to as a "signalling cascade" or a "second messenger pathway" and often results in a small stimulus eliciting a large response. Hormones and other signalling molecules may exit the sending cell by exocytosis or other means of membrane transport. The sending cell is typically of a specialised type. Its recipients may be of one type or several, as in the case of insulin, which triggers diverse and systemic effects. This book sheds new light in this exciting field of cell transportation research.
Host-Guest Polymer Complexes
This book is a printed edition of the Special Issue "Host-Guest Polymer Complexes" that was published in Polymers
Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Pawns of Justice
Justice Ron Goodman is a trial judge at the center of a high-profile medical malpractice case, and the stakes are enormous. When one of the defendants, Dr. DiTucci, is killed and another has his car blown up, Detective Jack Zangara, a friend of Goodman's, realizes that there is a connection between the case and the murder. Thus begins a complex game of treachery, deceit, and contract killings. The malpractice case centers around a woman who is near death as a result of a botched operation at a prominent New York hospital with particularly deep pockets-a ripe target for seven-figure insurance claims. But Dr. DiTucci's suspicious death only raises more questions for all involved: who killed hi...
