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Bone Marrow T Cells at the Center Stage in Immunological Memory
Increasing evidence supports the notion that bone marrow (BM) represents a relevant player in T cell responses, particularly in its role as a specialized organ for long-term memory. Memory T cells are enriched in the BM over long times after priming, and can be recruited to the periphery upon antigenic challenge. The articles in this research topic include discussions of whether these T cells are passing-through or truly resident, as well as a debate on the extent of proliferation of BM memory T cells. Original research articles in this collection include an analysis of the number of memory T cells found in different bones as well as effects of B cell depletion on T cell memory in the BM. T cells in the BM can influence a number of processes, from bone remodeling, control of cancer, to effects on hemopoiesis or Graft versus Host Disease (GVHD). This research topic contains several contributions to these topics including discussions on how to translate BM T cell knowledge into medicine.
Bone Cancer
Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone ...
Skeletal Tissue Mechanics
This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter
Protein and Amino acid nutrition
Protein and Amino Acid Nutrition describes the state of knowledge concerning the nutrition of proteins and amino acids. Topics range from the effect of some therapeutic agents on protein and amino acid nutrition, to species and age differences in amino acid requirements; utilization of D-amino acids; effect of proteins and amino acids on the growth of adult tissue in vitro; and amino acid requirements of animals and young adults. This volume is organized into 16 chapters and begins with an overview of the nutritional implications of the metabolic interrelationships of amino acids. The next chapters discuss experiments that tested the differences in amino acid requirements due to the differen...
RNA Spectroscopy
This volume looks at the different spectroscopic and biophysical methods used by researchers to study the structure and folding of RNA, and to follow their interactions with proteins. The chapters in this book cover topics such as single-molecule spectroscopy of multiple RNA species; surface plasmon resonance, MS or microcalorimetry for investigating molecular interactions with RNA; FTIR, SAXS, SANS and SRCD spectroscopies to analyze RNA structure; use of fluorescent nucleotides to map RNA-binding sites on proteins surfaces or CryoEM; and much more. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNA Spectroscopy: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing field.
Emerging immune functions of non-hematopoietic stromal cells
The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are ...
