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Conceiving Virtuality: From Art To Technology
This book provides new theoretical approaches to the subject of virtuality. All chapters reflect the importance of extending the analysis of the concept of “the virtual” to areas of knowledge that, until today, have not been fully included in its philosophical foundations. The respective chapters share new insights on art, media, psychic systems and technology, while also presenting new ways of articulating the concept of the virtual with regard to the main premises of Western thought. Given its thematic scope, this book is intended not only for a philosophical audience, but also for all scientists who have turned to the humanities in search of answers to their questions.
T Helper Cell Differentiation and Their Function
This book will focus on the differentiation and regulation of subsets of CD4+ T cells. It will also cover other aspects of research on these cells, which has made great advances in recent years, such as subsets’ plasticity and their role in healthy and disease conditions. The book provides researchers and graduate students with a cutting-edge and comprehensive overview of essential research on CD4+ T cells.
TH17 Cells in Health and Disease
“About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, pres...
Bernard de Mandeville's Tropology of Paradoxes
This book integrates studies on the thought of Bernard de Mandeville and other philosophers and historians of Modern Thought. The chapters reflect a rethinking of Mandeville’s legacy and, together, present a comprehensive approach to Mandeville’s work. The book is published on the occasion of the 300 years that have passed since the publication of the Fable of the Bees. Bernard de Mandeville disassembled the dichotomies of traditional moral thinking to show that the outcomes of the social action emerge as new, non-intentional effects from the combination of moral opposites, vice and virtue, in such a form that they lose their moral significance. The work of this great writer, philosopher and physician is interwoven with an awareness of the paradoxical nature of modern society and the challenges that this recognition brings to an adequate perspective on the historical world of modernity.
Fuzzy Logic in Action: Applications in Epidemiology and Beyond
Fuzzy Logic in Action: Applications in Epidemiology and Beyond, co-authored by Eduardo Massad, Neli Ortega, Laécio Barros, and Cláudio Struchiner is a remarkable achievement. The book brings a major paradigm shift to medical sciences exploring the use of fuzzy sets in epidemiology and medical diagnosis arena. The volume addresses the most significant topics in the broad areas of epidemiology, mathematical modeling and uncertainty, embodying them within the framework of fuzzy set and dynamic systems theory. Written by leading contributors to the area of epidemiology, medical informatics and mathematics, the book combines a very lucid and authoritative exposition of the fundamentals of fuzzy...
Regulation of Cytokine Gene Expression in Immunity and Diseases
This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presenting cutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
