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The Paradoxes of Longevity
An ever greater number of our contemporaries will reach a very much greater age than their ancestors. Longevity is one of the most fertile fields for paradoxes: it is clear that the same causes do not produce the same effects at the age of ten and at the age of one hundred! On the subject of longevity, the "recipe book" is far from having been written. Nevertheless, the Fondation IPSEN has chosen a few of these paradoxes to discuss and try and explain them.
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Aging and Cellular Defense Mechanisms
This volume shows how defence mechanisms such as DNA repair, production of heat shock and other stress proteins, enzymatic and non-enzymatic antioxidant defence systems, and poly (ADP-ribose) polymerase activation constitute an integrated network of critical importance for the aging process. There is an emphasis on growth factor deprivation and programmed cell death, and on the nervous and immune systems, in the framework of a molecular biology approach.
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Breakfast with the Centenarians
Learn the art of growing old from the supercentenarians living life to the fullest. It's said that life begins at 40 - but that number is constantly revised upwards as we live longer and longer. With the number of centenarians having quadrupled in the last thirty years, more of us can now hope to reach the 100-year mark than ever before. But how can we navigate this journey with grace, dignity and style? In this charming and informative book, Daniela Mari - the Italian doctor caring for some of the oldest people on the planet - draws on her experiences as a renowned gerontologist to reveal the science behind a healthy, happy old age. It turns out that the world's centenarians can teach us a thing or two about ageing well. And the secrets are not always what you'd think. Informed by the latest medical studies and incredible stories of individual longevity, Mari shows how our lifestyles can far surpass the influence of our genetics and why a daily glass of liquor isn't the end of the world. From our sleeping habits and diet to the crucial importance of our passions and interests, Breakfast with the Centenarians is the essential handbook for a fruitful and fulfilling old age.
Handbook of Immunosenescence
Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with con...
Discourses and Narrations in the Biosciences
Discourses and Narrations in the Biosciences investigates the forms of writing in which scientific claims are formulated and announced. Argumentative strategies, compositional rules, and figurative expressions in communication and narrativization of scientific knowledge are the focus of interdisciplinary contributions by humanities and science scholars. The first part of the book, dedicated to 'Rhetorical and Epistemological Aspects of Science Writing', addresses how scientific pursuits and methods feed into multi-level texts that generate responses within science, society, and culture. The second part, entitled 'Bioscientific Discourses and Narrations', examines popularisations and fictionalizations of science in relation to diversity, deviancy, ageing, illness, reproduction, the evolution of humankind, mathematical models of biomedical systems, and the myth of the heroic scientist. Assessing the narrative impetus and command of literary and meta-discoursive strategies shown by contemporary science writers enhances understanding of the methods and conventions through which the biosciences produce knowledge.
Evolutionary Thinking in Medicine
The aim of this edited book is to provide health professionals, across a wide variety of specialisms, with a targeted access to evolutionary medicine. Throughout the book, the views of both medical and evolutionary scientists on the latest relevant research is presented with a focus on practical implications. The inclusion of boxes explaining the theoretical background as well as both a glossary for technical terms and a lay summary for non- specialists enable medical researchers, public health professionals, policy makers, physicians, students, scholars and the public alike to quickly and easily access appropriate information. This edited volume is thus relevant to anyone keen on finding out how evolutionary medicine can improve the health and well-being of people.
Eco-immunology
This book represents a cutting-edge contribution giving an all-around perspective of eco-immunology today. Beside questions of the utmost importance for the whole community of immunologists, e.g, the intrinsic limits of immunological experiments performed at the bench on a limited number of selected models, the book covers several other facets of the eco-immunological approach, including host-parasite interactions, human aging and population immunology. Throughout the book the importance of population dynamics and evolutionary diversification of immune systems is frequently recalled, and makes the reader aware of the basic similarities and differences existing between humans and the models adopted for studying human immune system. The evidenced differences have been recently challenging the reliability of several established animal models and in the book it is discussed for the first time in analytical terms whether mice are reliable models of human inflammatory disorders.
