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Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase Modulation of Neuronal and Cardiovascular Signal Transduction
The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
Neuronal Calcium Sensor Proteins
Calcium signalling is an astonishing example how a simple caption can trigger and regulate an enormous variety of cellular and physiological responses. Ca2+-signalling routes very often involve Ca2+-binding proteins that sense changes in intracellular [Ca2+] and trigger cellular responses by regulating specific targets. One fascinating group among these Ca2+-sensors are the neuronal calcium sensor (NCS) proteins, named for their localisation in neuronal tissue (although there are reports of their expression in non-neuronal tissues as well). While recent excellent reviews have covered key aspects of this protein group, the field expanded in recent years making it more and more difficult to represent every facet of this ongoing research endeavour. This book is intended to represent properties of NCS proteins.
Adler's Physiology of the Eye
Written and designed to enhance your understanding of ocular function, structure, and anatomy, Adler's Physiology of the Eye is a classic, best-selling text that makes critical information easier to learn and retain. The fully revised 12th Edition continues the successful Adler’s approach that connects basic science and clinical aspects in a user-friendly, highly visual format—ideal for study, review, and exam preparation. It captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. Covers the full structure and function of the eye and its related anatomy and makes the connectio...
Photoreceptors and Calcium
This volume foxuses on the status of Ca2+ ions in regulation of phototransduction, light adaptation and the recovery phase in vertebrate photoreceptors. Particular emphasis is given to Ca2+-binding proteins and their targets, among them particulate guanylate cyclases, GPCR-coupled kinases and cyclic nucleotide-gated cation channels. The book also expands our understanding of events invovling Ca2+ in the retinal pigment epithelium, in synaptic transmission and secondary retinal neurons. A significant part of the book is dedicated to the role of Ca2+ in invertebrate phototransduction, the best-studied phospholipid-mediated signal transduction pathway. Several chapters explore association of gene defects with human retina disease and the generation of animal models of retinal degeneration.
Photostasis and Related Phenomena
Over the weekend of 21-23 February 1997, a small group gathered in Tallahassee, Florida, at the invitation of Ted Williams, to discuss "photo stasis and related topics." The majority of participants were former students and colleagues of Ted's, but an occasional outsider such as myself was generously included. The papers presented there are collected in this volume. The theory of photo stasis was first outlined in a landmark paper by John Penn and Ted, published in 1986 in Experimental Eye Research. They provided compelling data showing that, in the albino rat eye, levels of rhodopsin, outer-segment length, rhodopsin regeneration rate, and even, perhaps, rhodopsin packing density all depend ...
Principles and Practice of Ophthalmology
In 1994, Drs Albertand Jacobiec set a new standard for reference works on occular health and disease with Principles and Practice of Ophthalmology. Now, a second edition of this landmark 6 volume set encompasses all the very latest ophthalmic knowledge. It also retains the scholarship, encyclopaedic coverage, clinical focus, and rich illustrative detail that distinguished the first edition. No ophthalmologist can afford to be without this essential reference. Presents in depth discussions of virtually all important diseases and clinical approaches in ophthalmology written by hundreds of the most respected specialists in the field Encompasses the most up-to-date fundamental basic science conc...
Ancient Remedies for Modern Life
The Secrets to Healing, Resilience and Immunity With the Most Powerful Natural Medicine in History From the bestselling author of Keto Diet Long before the first pharmaceutical companies opened their doors in the 1850s, doctors treated people, not symptoms. And although we've become used to popping pills, patients have finally had it with the dangerous side effects, addiction and over-prescribing - and they're desperate for an alternative. Here's the good news: that alternative has been here all along in the form of ancient treatments used for eons in traditional Chinese, Ayurvedic and Greek medicine. Ancient Remedies for Modern Life is the first comprehensive layman's guide that will bring ...
