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Chromatin and Epigenetics
  • Language: en
  • Pages: 296

Chromatin and Epigenetics

Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields...

The Irish Metropolitan Magazine. ...
  • Language: en
  • Pages: 728

The Irish Metropolitan Magazine. ...

  • Type: Book
  • -
  • Published: 1857
  • -
  • Publisher: Unknown

None

Point Mutation
  • Language: en
  • Pages: 356

Point Mutation

This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world.

The Irish Metropolitan Magazine
  • Language: en
  • Pages: 730

The Irish Metropolitan Magazine

Reprint of the original, first published in 1857.

Accounts and Papers
  • Language: en
  • Pages: 328

Accounts and Papers

  • Type: Book
  • -
  • Published: 1813
  • -
  • Publisher: Unknown

None

Machine Learning and Principles and Practice of Knowledge Discovery in Databases
  • Language: en
  • Pages: 499

Machine Learning and Principles and Practice of Knowledge Discovery in Databases

This volume constitutes the papers of several workshops which were held in conjunction with the International Workshops of ECML PKDD 2022 on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, ECML PKDD 2022, held in Grenoble, France, during September 19–23, 2022. The 73 revised full papers and 6 short papers presented in this book were carefully reviewed and selected from 143 submissions. ECML PKDD 2022 presents the following five workshops: Workshop on Data Science for Social Good (SoGood 2022) Workshop on New Frontiers in Mining Complex Patterns (NFMCP 2022) Workshop on Explainable Knowledge Discovery in Data Mining (XKDD 2022) Workshop on Uplift Modeling (UMOD 2022) Workshop on IoT, Edge and Mobile for Embedded Machine Learning (ITEM 2022) Workshop on Mining Data for Financial Application (MIDAS 2022) Workshop on Machine Learning for Cybersecurity (MLCS 2022) Workshop on Machine Learning for Buildings Energy Management (MLBEM 2022) Workshop on Machine Learning for Pharma and Healthcare Applications (PharML 2022) Workshop on Data Analysis in Life Science (DALS 2022) Workshop on IoT Streams for Predictive Maintenance (IoT-PdM 2022)

Corticosteroids
  • Language: en
  • Pages: 222

Corticosteroids

Corticosteroids are mainly used to reduce inflammation and suppress the immune system. Corticosteroids will only be prescribed if the potential benefits of treatment outweigh the risks. They will also be prescribed at the lowest effective dose for the shortest possible time. This book will strive to highlight the importance of corticosteroids, to focus on minimizing side effects, to monitor and sensitize the population on the potential adverse effects of misuse, to provide additional knowledge about the design and development of new drug delivery systems loaded with corticosteroids potentially useful in the treatment of chronic inflammatory-based diseases, and to reduce inflammation and affect the immune system. The major objective of this book will be to present the information in a lucid, condensed, and cohesive form and to specially cater to the needs of readers in medicine and pharmacy.

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response
  • Language: en
  • Pages: 1671

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response

Volume I.A An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international ...

Final Wicket
  • Language: en
  • Pages: 632

Final Wicket

While cricket remains a national game today, at the beginning of the Twentieth Century, it was THE national game. Cricketers were the sporting icons of their age, as footballers are today.When the call to arms was made in 1914 and the years of war that followed, it was answered in droves by young men including Test and First Class cricketers. The machine guns and gas of the Western Front and other theatres did not discriminate and many hundreds of these star performers perished alongside their lesser known comrades. The author has researched the lives and deaths of over 200 top class cricketers who made the ultimate sacrifice. He includes not just British players but those from the Empire. The enormity of the horror and wholesale loss of life during The Great War is well demonstrated by these moving biographies.

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine
  • Language: en
  • Pages: 657

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are nec...