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Sequence-Based Classification of Select Agents
  • Language: en
  • Pages: 236

Sequence-Based Classification of Select Agents

Select Agents are defined in regulations through a list of names of particularly dangerous known bacteria, viruses, toxins, and fungi. However, natural variation and intentional genetic modification blur the boundaries of any discrete Select Agent list based on names. Access to technologies that can generate or 'synthesize' any DNA sequence is expanding, making it easier and less expensive for researchers, industry scientists, and amateur users to create organisms without needing to obtain samples of existing stocks or cultures. This has led to growing concerns that these DNA synthesis technologies might be used to synthesize Select Agents, modify such agents by introducing small changes to ...

Innovation, Dual Use, and Security
  • Language: en
  • Pages: 367

Innovation, Dual Use, and Security

  • Type: Book
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  • Published: 2012-03-30
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  • Publisher: MIT Press

A framework for assessing the security risks of emerging dual-use technologies and devising tailored governance strategies is proposed and applied to contemporary case studies. Recent advances in disciplines such as biotechnology, nanotechnology, and neuropharmacology entail a “dual-use dilemma” because they promise benefits for human health and welfare yet pose the risk of misuse for hostile purposes. The emerging field of synthetic genomics, for example, can produce custom DNA molecules for life-saving drugs but also makes possible the creation of deadly viral agents for biological warfare or terrorism. The challenge for policymakers is to prevent the misuse of these new technologies w...

Self-Governance in Science
  • Language: en
  • Pages: 317

Self-Governance in Science

A comprehensive introduction to the history, theory, and policy implications of self-governance in commercial and academic science communities.

Mapping and Sequencing the Human Genome
  • Language: en
  • Pages: 128

Mapping and Sequencing the Human Genome

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Defense Against Biological Attacks
  • Language: en
  • Pages: 332

Defense Against Biological Attacks

  • Type: Book
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  • Published: 2019-03-30
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  • Publisher: Springer

This first volume of a two-volume set describes general aspects, such as the historical view on the topic, the role of information distribution and preparedness of health-care systems and preparedness in emergency cases. Part two describes and discusseses in detail the pathogens and toxins that are potentially used for biological attacks. As such, the book is a valuable resource for faculties engaged in molecular biology, genetic engineering, neurology, biodefense, biosafety & biosecurity, virology, and infectious disease programs, as well as professional medical research organizations.

Mapping our genes : the genome projects : how big, how fast?
  • Language: en
  • Pages: 215

Mapping our genes : the genome projects : how big, how fast?

None

Laboratory Biorisk Management
  • Language: en
  • Pages: 198

Laboratory Biorisk Management

  • Type: Book
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  • Published: 2015-12-01
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  • Publisher: CRC Press

Over the past two decades bioscience facilities worldwide have experienced multiple safety and security incidents, including many notable incidents at so-called "sophisticated facilities" in North America and Western Europe. This demonstrates that a system based solely on biosafety levels and security regulations may not be sufficient. Setting the stage for a substantively different approach for managing the risks of working with biological agents in laboratories, Laboratory Biorisk Management: Biosafety and Biosecurity introduces the concept of biorisk management—a new paradigm that encompasses both laboratory biosafety and biosecurity. The book also provides laboratory managers and direc...

University of British Columbia Law Review
  • Language: en
  • Pages: 902

University of British Columbia Law Review

  • Type: Book
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  • Published: 2016
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  • Publisher: Unknown

None

Review of the Department of Energy's Genomics: GTL Program
  • Language: en
  • Pages: 102

Review of the Department of Energy's Genomics: GTL Program

The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's res...

The Third Domain
  • Language: en
  • Pages: 313

The Third Domain

The Third Domain is the untold story of how the discovery of a new form of life-first ridiculed, then ignored for the past thirty years by mainstream scientists-is revolutionizing science, industry, and even our search for extraterrestrial life. Classification is a serious issue for science: if you don't know what you're looking at, how can you interpret what you see? Starting with Carolus Linnaeus in the 17th century, scientists have long struggled to order and categorize the many forms of life on Earth. But by the early 20th century the tree of life seemed to have stabilized, with two main domains of life at its roots: single-celled and multi-celled organisms. All creatures fit into one of...