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Biologics in Rheumatology
Significant progress has been acquired in the treatment of rheumatic conditions with the introduction of biologic therapies, which has enabled better control of disease activity and improved patients' long-term outcome. Apart from several biologic treatments already licensed for use in autoimmune rheumatic conditions, numerous other agents are currently under investigation. This rapid expansion of the therapeutic armamentarium requires a critical analysis of individual biologic options and their clinical indications, in order to facilitate the optimal use of these new therapies. The authors felt that a comprehensive book revisiting all the evidence available regarding the efficacy, cost-effe...
Sex Bias in Autoimmunity: From Animal Models to Clinical Research and Applications
Autoimmune diseases are characterized by an abnormal and self-directed immune response leading to damage and dysfunction of multiple organs and tissues. Most autoimmune diseases are recognized as affecting disproportionately more women than men, suggesting a crucial role of sex hormones in modulating immune responses, with estrogens being postulated as enhancing autoimmunity and androgens playing a protective role. It is also widely acknowledged that there is an overwhelming male bias in non-human (animal) studies of autoimmune diseases, while studies of both sexes in human research frequently fail to analyze results by sex. Underrepresentation of females in animal models of autoimmune disea...
Oxford Textbook of Sjögren's Syndrome
Oxford Textbook of Sjögren's Syndrome is an authoritative resource for everyday practice and reference. Suitable for rheumatologists, ophthalmologists, oral physicians, specialist nurses, neurologists, oncologists, general medics, and dentists.
New Insights into Autoinflammatory Diseases: From Bench to Bedside
Systemic autoinflammatory diseases (SAIDs) are a growing group of rare disorders caused by dysregulation of the innate immune system leading to episodes of organ-specific and systemic inflammation. Autoinflammation as a distinct disease category was first reported in 1999 as a group of monogenic disorders with resultant activation of the inflammasome and cytokine excess, presenting as periodic fever and inflammation in serous membranes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions, and more than 30 associated genes have been identified. Disease severity varies from mild to life threatening. Advances in the understanding of the pathogenetic role of interleukin-1, have opened new promising horizons in the treatment of these patients, and significantly altered disease outcome.
Medicine for MRCP
Medicine for MRCP provides a comprehensive review of the material that you need to pass the MRCP Parts 1 and 2 written papers. The twenty-seven chapters mapped out to the RCP syllabus, cover all areas from molecular medicine and genetics, through to medical law and ethics. Written by specialist contributors and educational experts, the content is carefully crafted to build your understanding for both papers. Each chapter begins with the basic science required for Part 1, before covering clinical medicine for Part 1, Part 2 and the PACES examinations. To ensure effective revision, material is presented in short sections with bullet lists, tables, and boxes. Over 150 drawings and photos illustrate key principles and clinical topics making them easier to retain. References to evidence-based protocols and directions to further reading allow for deeper understanding. Candidates can review their progress via the 180 end-of chapter self-assessment questions. Drawing on the authors' expertise, Medicine for MRCP is the ideal companion for the MRCP as well as a useful reference guide for practicing medical doctors.
