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This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, the design of studies in which missing data is anticipated. Each chapter will be written by an expert conducting research in the topic of that chapter. As a collection, the chapters would be intended to serve as a guidance for statisticians designing trials.
This book, which is part of a two-volume handbook set, gives a comprehensive description of recent developments in materials science and manufacturing technology, aiming primarily at its applications in biomedical science, advanced engineering materials, conventional/non-conventional manufacturing techniques, sustainable engineering design, and related domains. Manufacturing Engineering and Materials Science: Tools and Applications provides state-of-the-art research conducted in the fields of technological advancements in surface engineering, tribology, additive manufacturing, precision manufacturing, electromechanical systems, and computer-assisted design and manufacturing. The book captures emerging areas of materials science and advanced manufacturing engineering and presents the most recent trends in research for emerging researchers, field engineers, and academic professionals.
The dynamics of farm mechanization in pulses is a challenging issue to address. This text emphasizes the necessary keys in building and operating farm mechanization in pulses to complete the task by research, sensitization and policy decision. The authors believe that the book will help in implementation of farm mechanization in pulses whichmay be achieved with sensitization of farmers for adoption of recommendations, scientists to work on wide spectrum of researchable issues and policy makers to develop farmers friendly strong policy. The essence of the book will help in doubling the farmers income, reducing import of pulses and vanishing mal-nutrition formthe country.
The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.
This book comprises 41 s dealing various issues, prospects and importance of conservation agriculture practices followed across different regions with special emphasis on rainfed regions. We hope this book on conservation agriculture will be highly useful to researchers, scientists, students, farmers and land managers for efficient and sustainable management of natural resources.
The rapidly evolving field of environmental toxicology involves the study of toxic compounds and their effect on living organisms, as well as their fate within the natural environment. Since publication of the first edition, Introduction to Environmental Toxicology has found a secure place among the major texts and references in this field. Introduction to Environmental Toxicology, Third Edition seamlessly covers processes and impacts from the molecular level all the way up to population levels. While retaining the strengths of previous editions, the third edition includes a new chapter on fluoride, an update on endocrine disruption, a discussion of the use of models to reconstruct concentration-response curves, expansion of the metals chapter, and new developments in ecological risk assessment for management decisions at site to regional scales. It is an ideal text for introducing students to the fields of ecotoxicology and risk assessment.
This volume contains the proceedings of the AMS Special Session on Discrete Geometry and Algebraic Combinatorics held on January 11, 2013, in San Diego, California. The collection of articles in this volume is devoted to packings of metric spaces and related questions, and contains new results as well as surveys of some areas of discrete geometry. This volume consists of papers on combinatorics of transportation polytopes, including results on the diameter of graphs of such polytopes; the generalized Steiner problem and related topics of the minimal fillings theory; a survey of distance graphs and graphs of diameters, and a group of papers on applications of algebraic combinatorics to packings of metric spaces including sphere packings and topics in coding theory. In particular, this volume presents a new approach to duality in sphere packing based on the Poisson summation formula, applications of semidefinite programming to spherical codes and equiangular lines, new results in list decoding of a family of algebraic codes, and constructions of bent and semi-bent functions.
Towards Hydrogen Infrastructure: Advances and Challenges in Preparing for the Hydrogen Economy lays out the fundamental needs and processes of a potential hydrogen-based economy. This book begins by outlining the processes, theory, and technology underlying hydrogen energy, from production to storage and dissemination. Each chapter outlines the potential and the hurdles for developing each element toward a workable hydrogen infrastructure. The later parts consider the social, and environmental issues surrounding the hydrogen economy, and suggest updated governmental policies. Presenting the needs of hydrogen energy infrastructure from development to practical implementation, - Provides a basic overview of hydrogen energy processes, from production and storage to transportation and use. - Considers in detail the potential needs and opportunities of future hydrogen economic infrastructure, identifies necessary developments, and lays out a roadmap toward a successful transition. - Presents safety and environmental considerations for the potential hydrogen economy, and proposes governmental and regulatory policies to enable effective, safe, and sustainable use.
"DVD-ROM which includes the full text plus video clips of the author demonstrating many of the techniques.