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Molecular Aspects of Human Cytomegalovirus Diseases
In this book the current knowledge on human cytomegalovirus (HCMV) as a human pathogen is lucidly summarized, bringing the reader fully up to date with current knowledge concerning HCMV and all the known clincial and medical aspects of diseases caused by, and associated with, HCMV. The book is divided into four parts: (I) Human cytomegalovirus and human diseases; (II) human cytomegalovirus infections and the immunocompromised host; (III) diagnosis, treatment, and prevention of human cytomegalovirus and human diseases; and (IV) molecular aspects of human cytomegalovirus. Each part is put together from chapters written by experts in the respective fields, providing basic medical and molecular knowledge in addition to more specific understanding of HCMV infections.
Manifestations of Cytomegalovirus Infection
Cytomegalovirus (CMV) is carried by 50 100% of the worlds population throughout their lives. Consequences are most readily seen in immunocompromised individuals such as organ transplant recipients, HIV-infected patients and new born infants. This book gives an in-depth view of manifestations of CMV infection in immunocompromised individuals: how it affects the immune system and how it is diagnosed and treated. The book also sheds light on the epidemiology and impact of CMV in sub-Saharan Africa, and also associations with age related disease that are more commonly seen in the western world. It particularly details a recent discovery between CMV and tumour immuno-biology. The book explores the development of a few compounds and also highlights the need to discover novel antiviral agents in future.
Congenital Cytomegalovirus Infection
Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, with a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. Since economic aspects are gaining more and more importance in health politics, one chapter is dedicated to this issue in the context of congenital CMV infection. The content is based on the latest scientific findings and written in an understandable manner, allowing persons not working in the field of congenital CMV to also profit from it. Thus, this book is of interest for medical doctors, nurses, midwives, economists, but also for men and women who want to inform themselves about this topic.
Human Cytomegalovirus Infection
Human cytomegalovirus (CMV), a member of the human herpesviruses, is a deoxyribonucleic acid virus that is ubiquitous in the world. After primary infection, CMV develops a latent state; however, when the defense of the immune system decreases in a host, it can reactivate. Human cytomegalovirus infections are acquired via several ways. CMV is spread through contact with infected bodily fluids in humans, whereas it occurs in pregnant women through close contact with young children or through sexual transmission. The clinical manifestations consist of non-specific symptoms or clinical findings. However, the patients with acute CMV infections are generally asymptomatic. Congenital CMV infection ...
Congenital Cytomegalovirus Infection
This second edition updates the reader on the most common intrauterine transmitted viral infection, CMV. The history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed in detail. Further a section specifically dedicated to prevention measures is included to the new edition. The chapter on virus-host interaction for defense and transmission is elaborately updated.
New Aspects of CMV-related Immunopathology
Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of C...
Human Cytomegalovirus
This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
Cytomegaloviruses
Named for the enlarged, inclusion-bearing cells characteristic of infection by these viruses, cytomegaloviruses present a significant challenge to both microbiologist and immunologist. Although most primary infections in humans are subclinical, cytomegalovirus can be associated with a wide spectrum of disease, particularly when infection occurs in the immuno compromised individual or as a result of congenital or perinatal infection. Although reinfection with cytomegalovirus has been demonstrated, most recurrent and persistent infections result from the reactivation of latent virus. Cytomegaloviruses, like other members of the Herpesviridae family, have the capacity to establish latency after...
