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Fibrosis Research
Leading investigators review the highlights of current fibrosis research and the experimental methodologies used uncover the mechanisms that drive it. In their discussion of research methodologies utilizing cultured cells to model various aspects of the fibrotic response in vitro, the authors describe the isolation, characterization, and propagation of mesenchymal cells, and highlight the similarities and differences between methods that are appropriate for different types of fibroblasts. Approaches for studying collagen gene regulation and TGF-b production are also discussed, along with experimental methodologies utilizing animal models to study the pathogenesis of fibrosis. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Car Safety Wars
Car Safety Wars is a gripping history of the hundred-year struggle to improve the safety of American automobiles and save lives on the highways. Described as the “equivalent of war” by the Supreme Court, the battle involved the automobile industry, unsung and long-forgotten safety heroes, at least six US Presidents, a reluctant Congress, new auto technologies, and, most of all, the mindset of the American public: would they demand and be willing to pay for safer cars? The “Car Safety Wars” were at first won by consumers and safety advocates. The major victory was the enactment in 1966 of a ground breaking federal safety law. The safety act was pushed through Congress over the bitter ...
No Accident
It is possible to eliminate death and serious injury from Canada’s roads. In other jurisdictions, the European Union, centres in the United States, and at least one automotive company aim to achieve comparable results as early as 2020. In Canada, though, citizens must turn their thinking on its head and make road safety a national priority. Since the motor vehicle first went into mass production, the driver has taken most of the blame for its failures. In a world where each person’s safety is dependent on a system in which millions of drivers must drive perfectly over billions of hours behind the wheel, failure on a massive scale has been the result. When we neglect the central role of t...
Tourism and Socio-Economic Transformation of Rural Areas
This book aims to fill a gap in the current literature by tracing the rural transformation process and the development of rural tourism functions in Poland over the last 30 years. It examines the socioeconomic transformation between 1989 and 2019 that resulted in the formation and development of Polish rural tourism and the various practices associated with it. This timely topic is addressed in a central and eastern European context and sparks interest in further in-depth analysis due the diversity and magnitude of the transformation processes undertaken by the Polish rural areas. Since Polish rural areas constitute as much as 30% of the total rural areas in all new European Union member states, this book adds value through an in-depth statistical analysis of the pace of socioeconomic changes in Polish rural areas. It delves into the creation and consumption of tourism services locally, as well as the impact of global trends on the development of rural tourism in Poland. This book will be of interest to economists, sociologists, political scientists and postgraduate students across eastern and central Europe who deal with rural tourism issues.
In Re Terry
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The Anti-Stupidity Book
Stupidity. What is it? Is is just something we see our neighbors and parents/kids do (and members of the opposite political party)? Or is it something more? Why does it seem to be so universal? Are there fundamentals of stupidity that can be recognized? These are the questions discussed in this volume. It presents six fundamentals of stupidity that lead to the stupid choices we see all around us. Included among these are the belief that there are no moral values, that God does not exist, and that it is acceptable to become addicted and to treat others badly and be proud. In the end, we see that the only sure way to avoid the fundamentals of stupidity is through the saving power of Jesus Christ.
