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Biomaterial-Related Infections
The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has bee...
Plant Extracts
Plant extracts are widely used for therapeutic purposes. The vegetal origin of these products satisfies people’s desire to cure themselves with natural drugs; this aspect, together with effectiveness and regulatory opportunities, is the base of the broad modern use of medicinal plants. Traditional uses and novel biological effects allow the availability of an extraordinarily high number of different compounds with formidable therapeutic potential. Nevertheless, pitfalls are hidden behind poor pharmacological and toxicological knowledge of plant extracts, nonstandardized methods of extraction, and undefined and nonrepeatable qualitative and quantitative composition. In this context, novel experimental studies on plant products and appreciated and are necessary to reinforce the scientific soundness of phytotherapy. This book aims to respond to this medical need comprehensively highlighting the newest discoveries in vegetal resources with an emphasis on pharmacological activity.
Candida Biofilms
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Multispecies Biofilms
In an age of antibiotic resistant infections, the study of biofilms is increasingly important. Microbes more than often exist in complex multi-species or polymicrobial communities, making infections difficult to detect, diagnose and treat. Given the increased focus on studying biofilms in research and laboratory settings, particularly under conditions that closely mimic the clinical state, it is important to get an overview of the recent methods, model systems and tools being developed and employed in this context. This book offers readers the opportunity to learn more about current methods being used in the investigation of multi-species biofilms, both in vivo and in vitro. For this, the bo...
Advances in Microbiology, Infectious Diseases and Public Health
This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention. The book series publishes review and original research contributions, short reports as well as guest edited thematic book volumes. All contributions will be published online first and collected in book volumes. There are no publication costs. Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2018 Impact Factor: 2.126.
Fungal Pathogenesis in Humans
Dear Colleagues, Cancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunistic fungal infections are probably the deadliest threat to these patients due to their difficult early diagnosis, the limited effect of antifungal drugs and the appearance of resistances. In recent years, a considerable effort has been devoted to investigating the role of many virulence traits in the pathogenic outcome of fungal infections. New virulence factors (hypoxia adaptatio...
by Celia's arbour
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