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Ocular Circulation and Neovascularization
Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotideals...
Uveitis Scoring System
Advances in the understanding of the pathogenetic mechanisms involved in uveitis and uveoretinitis led to the introduction of various new therapeuticmodalities for these diseases, thus raising the need for a comprehensive and reproducible standard scoring system. This monograph is the end result of extensive studies and presents a universal grading system that reflects both intraocular inflammatory activity and visual acuity and can beused as a standard means of classification throughout the world.
Current Topics in Contact Dermatitis
In recent years the field of contact dermatitis has increased greatly in importance in dermatology. The variety of exogenous, environmental ly caused dermatoses has undoubtedly expanded over the past few de cades with the increasing number of potentially toxic chemicals, the changes in lifestyle, and the greater life expectancy in industrialized societies. The value of international cooperation in this field has long been realized and acted upon by the International Contact Dermatitis Re search Group (ICDRG). By 1975 the international journal Contact Dermatitis had been founded under the editorship of C. D. Calnan. Thanks largely to the ICDRG and Contact Dermatitis, there were, by 1986, enou...
Angiogenesis
Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states an...
Antiangiogenic Cancer Therapy
Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bev
Cyclosporin
Cyclosporin has had a remarkable effect on clinical organ transplantation. Prior to its introduction, considerable advances had been made in the grafting of vital organs, particularly the kidney, heart and liver. In many developed countries, however, transplantation was not considered wo-rthwhile in terms of gain for the investment of resources. The improved results of kidney grafts following the use of cyclosporin has changed this attitude. For all types of organ transplantation, cyclosporin has resulted in an improvement of functional graft survival and has allowed a reduction in steroid dose and, in some cases, no steroids at all. It has permitted the first successful experimental transpl...
Ed Ruscha
One of the most consistently inventive artists of recent times, Los Angeles-based Ed Ruscha has been a pioneer in the use of language and imagery drawn from the popular media. From his early powerful word paintings to his influential artist books of the sixties and seventies to his recent colorful views of generic mountains, Ruscha has investigated the spaces between highways and journeys, images and words, abstraction and representation, public imagery and the contemporary landscape. In this publication, which accompanies a major retrospective exhibition organized by the Hirshhorn Museum and Sculpture Garden in Washington, D.C. and the Museum of Modern Art, Oxford, Neal Benezra, Kerry Brougher, and Phyllis Rosenzweig focus on all aspects of Ruscha's career, revealing him not merely as an artist closely linked with Los Angeles, but as an important international figure in contemporary art.
