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This book evaluates the progress of schizophrenia science by summarizing what is known about how patients with the illness differ from healthy people. The tools of meta-analysis are first explained and then employed to make the strength and consistency of these differences explicit. Beginning with the study of symptoms, then moving through the search for objective disease markers, findings on the cognitive functions, structure, physiology, chemistry, and development of the brain, this book is a journey into the enigma of madness and its science. What emerges is an illness that reveals itself most strongly in thought processes, not biology. Schizophrenia is an anomaly at the frontier of mind and brain, but In Search of Madness points the way to its solution.
The development of materials for any replacement or regeneration application should be based on the thorough understanding of the structure to be substituted. This is true in many fields, but particularly exigent in substitution and regeneration medicine. The demands upon the material properties largely depend on the site of application and the function it has to restore. Ideally, a replacement material should mimic the living tissue from a mechanical, chemical, biological and functional point of view. Of course this is much easier to write down than to implement in clinical practice. Mineralized tissues such as bones, tooth and shells have attracted, in the last few years, considerable inte...
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