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Biomedical Research, Medicine, and Disease
Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in th...
A Demographic Uniqueness of Kangra
The Ghrits inhabiting the Kangra Valley is a demographic uniqueness of the Kangra hills. An ICS officer in 1848 described the Ghrits (Ghirath) physiognomy as peculiar to the Kangra hills. Throughout the country this caste is found only in Kangra hills of Himachal Pradesh. Many people believe that Ghrit is a puranic caste and the Ghrits are the original inhabitants of Trigarta of the Mahabharta period, which also led to locate the Trigarta in Kangra. However, the aboriginality of the Ghrits in Kangra has not been supported by any fact and it is based just on the surmises and suppositions. In the present work the origin of the Ghrit caste has been traced with the help of physiognomic, historic...
Water Soluble Vitamins
The discovery of vitamins in the early 1900s, their later chemical characterization and the clarification of pivotal metabolic functions are sequential aspects of a brilliant chapter in the history of modern nutritional sciences and medicine. The name, derived from “vital-amines”, indicates their elementary metabolic key functions in human metabolism. Vitamins are truly families of compounds, which include precursors and various free and bound forms, all with individual roles in metabolism and function. A more recent approach therefore searches for the components, the understanding of their roles in physiology and pathology as well as looking for novel pharmacological applications. When ...
Genetic Engineering
Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allow...
Wildlife Disease and Health in Conservation
Provides wildlife professionals with cutting-edge scientific information on the most damaging and newly emerging wildlife diseases. Wildlife diseases and their implications are at the forefront of many sectors of scientific endeavor, especially in the wake of the COVID-19 pandemic. Nearly 60 percent of all human diseases and 75 percent of all emerging infectious diseases are zoonotic. Edited by pioneering wildlife veterinarians David A. Jessup and Robin W. Radcliffe, Wildlife Disease and Health in Conservation explores the origins and impacts of as well as the responses to the most damaging and persistent diseases currently threatening wildlife conservation. Focusing mainly on newer, invasiv...
Apoptotic and Non-apoptotic Cell Death
This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.
Microbial Strategies for Vegetable Production
This book provides a comprehensive information on basic and applied concepts of microbesial strategies adopted for the improvement of vegetables grown in various production systems. The beneficial role of soil microbes including plant growth promoting rhizobacteria (PGPR), nitrogen fixers, and phosphate-solubilizing bacteria in the improvement of vegetables grown both in normal and contaminated soils is discussed. The role of PGPR in tomato production is dealt separately. The impact of heavy metals on different vegetables and abatement of metal toxicity following metal tolerant PGPR and their consequential impact on vegetables grown in metal polluted soil is discussed. Moreover, recent advances in the management of vegetable diseases employing PGPR are addressed. This volume is therefore of special interest to both academics, professionals and practitioners working in the field of vegetable farming/horticulture, microbiology and plant protection sciences.
