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Antibiotics
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Official Register 2008
The Official Register is published annually to provide ready access to governing documents, statistics, and general information about ASCE for leadership, members, and staff. It includes the ASCE constitution, bylaws, rules, and code of ethics; as well as information about member qualifications and benefits; section and branch contacts; technical, professional, educational, and student activities; committee appointments; past and present officers; honors and awards; CERF/IIEC; the ASCE Foundation; and staff contacts. There are also sections with constitution, bylaws, and committees for Geo-Institute; Structural Engineering Institute (SEI); Environmental and Water Resources Institute (EWRI); Architectural Engineering Institute (AEI); Coasts, Oceans, Ports, and Rivers Institute (COPRI); Construction Institute (CI); and Transportation & Development Institute (T&DI).
Metal-based Anticancer Agents
Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.
Lloyd's Register of Shipping 1894 Sailing Vessels
The Lloyd's Register of Shipping records the details of merchant vessels over 100 gross tonnes, which are self-propelled and sea-going, regardless of classification. Before the time, only those vessels classed by Lloyd's Register were listed. Vessels are listed alphabetically by their current name.
Active Flow and Combustion Control 2021
The book reports on the latest theoretical and experimental findings in the field of active flow and combustion control, in the context of energy conversion for power and propulsion systems. It covers new developments in actuator technology and sensing, robust and optimal open- and closed-loop control, model reduction for control purposes, and unsteady turbine cooling and performance, among other relevant topics. Gathering contributions to the Active Flow and Combustion Control (AFCC 2021), held virtually on September 28-29, 2021, from the Technische Universität Berlin, Germany, this book describes research that has been carried out within, and supported by, the collaborative research center SFB 1029 on “Substantial efficiency increase in gas turbines through direct use of coupled unsteady combustion and flow dynamics”, and funded by the German Research Foundation (DFG). It highlights theoretical and practical aspects, and corresponding solutions, that are important for the development of future energy conversion systems, thus offering a timely guide for researchers and practitioners in the field of aeronautics, turbomachinery, control and combustion.
GeNeDis 2018
The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.
