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Antibiotics
Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.
Motor System Disorders, Part I
Motor System Disorders: Normal Physiology and Function and Neuromuscular Disorders summarizes recent advances and best practice for understanding normal physiology and function of the larger motor system as well as the diagnosis, course, and treatment of neuromuscular disorders. The work will include neuroanatomy, circuits and synapses. It discusses how different parts of the brain contribute to motor control, including both vestibular and cerebellar motor control, as well as the influences of the parietal and frontal lobes. Diagnostic methods include genetic evaluation, electrodiagnosis, pathology, and brain imaging. Neuromuscular disorders of both children and adults will be included. - Identifies normal motor control physiology and function, including neuroanatomy, circuits, and synapses - Discusses vestibular and cerebral motor control and contributions of parietal and frontal lobes - Provides diagnostic methods, including genetic evaluation, electrodiagnosis, brain imaging, and pathology analyses - Summarizes the diagnosis, course, and best practice treatment of neuromuscular disorders - Explores neuromuscular disorders in adults and children
Bulletin
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Extracellular Matrix: Pathobiology and Signaling
Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, ve...
Bulletin
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Semantic Applications
This book describes methodologies for developing semantic applications. Semantic applications are software applications which explicitly or implicitly use the semantics, i.e. the meaning of a domain terminology, in order to improve usability, correctness, and completeness. An example is semantic search, where synonyms and related terms are used for enriching the results of a simple text-based search. Ontologies, thesauri or controlled vocabularies are the centerpiece of semantic applications. The book includes technological and architectural best practices for corporate use. The authors are experts from industry and academia with experience in developing semantic applications.
Dynamic Response and Failure of Composite Materials
This book gathers the latest advances and innovations in the field of dynamic loads and testing of composite materials and sandwich structures, as presented by international researchers and engineers at the International Symposium on Dynamic Response and Failure of Composite Materials (DRAF), held in Ischia, Italy, on June 21–24, 2022. Contributions include a wide range of topics such as low and high velocity impacts, smart composites, hull slamming, shock and blast, hail and bird impact, damage resistance and tolerance, failure mechanisms, composite structures, delamination and fractures, progressive damage modeling, micromechanics, ballistic impacts, ceramic and CMC, auxetic materials and structures, additive manufacturing, crashworthiness, green composites, and structural health monitoring.
Light and Darkness in Ancient Greek Myth and Religion
Light and Darkness in Ancient Greek Myth and Religion is a ground-breaking volume dedicated to a thorough examination of the well known empirical categories of light and darkness as it relates to modes of thought, beliefs and social behavior in Greek culture. With a systematic and multi-disciplinary approach, the book elucidates the light/darkness dichotomy in color semantics, appearance and concealment of divinities and creatures of darkness, the eye sight and the insight vision, and the role of the mystic or cultic.
Lignite in Greece
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