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Fast Online Control based on Homotopies for Systems subject to Time-Varying Constraints
The integration of intelligent, autonomously acting systems into modern society is a rapidly growing field. After robots are established for simple, recurring processes in industry and everyday life, more complex tasks are of interest which require the systems to consider the environment in their decision making process. In the future, intelligent systems will get access to fields like autonomous driving cars, unmanned aerial vehicle (UAV), manufacturing processes, household, or the assistance to people in need of care. The fast calculation of optimal circumventing trajectories is therefore an essential component to be able to integrate intelligent systems into our environment at all. The am...
Robust Model Predictive Control for Large-Scale Manufacturing Systems subject to Uncertainties
Large scale manufacturing systems are often run with constant process parameters although continuous and abrupt disturbances influence the process. To reduce quality variations and scrap, a closed-loop control of the process variables becomes indispensable. In this thesis, a modeling and control framework for multistage manufacturing systems is developed, in which the systems are subject to abrupt faults, such as component defects, and continuous disturbances. In this context, three main topics are considered: the development of a modeling framework, the design of robust distributed controllers, and the application of both to the models of a real hot stamping line. The focus of all topics is on the control of the product properties considering the available knowledge of faults and disturbances.
Vitamin D
Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenom...
Bone Cancer
Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastase...
Gadd45 Stress Sensor Genes
Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to ph...
Sunlight, Vitamin D and Skin Cancer
The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Gadd45 Stress Sensor Genes
This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.
New Developments in the Appalachian-Caledonian-Variscan Orogen
"This volume provides a comprehensive overview of our understanding of the evolution of the Appalachian-Caledonian-Variscan orogen. It takes the reader along a clockwise path around the North Atlantic Ocean from the U.S. and Canadian Appalachians; to the Caledonides of Spitsbergen, Scandinavia, Scotland and Ireland; and thence south to the Variscides of Morocco"--
Max Eicke
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