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Organic synthesis is a vibrant and rapidly evolving field; we can now cyclize amines directly onto alkenes. Like the first two books in this series, Organic Synthesis: State of the Art 2003-2005 and Organic Synthesis: State of the Art 2005-2007, this reference leads readers quickly to the most important recent developments. Two years of Taber's popular weekly online column, "Organic Chemistry Highlights", as featured on the organic-chemistry.org website, are consolidated here, with cumulative indices of all three volumes in this series. Important topics that are covered range from powerful new methods for C-C bond construction to asymmetric organocatalysis and direct C-H functionalization. This go-to reference focuses on the most important recent developments in organic synthesis, and includes a succinct analysis of the significance and applicability of each new synthetic method. It details and analyzes more than twenty complex total syntheses, including the Sammakia synthesis of the Macrolide RK-397, the Ley synthesis of Rapamycin, and the Kobayashi synthesis of (-)-Norzoanthamine.
Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic...
A concise reference that summarizes the most important current developments in organic synthesis.
Sets forth an important group of environmentally friendly organic reactions With contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (C–C), carbon-nitrogen (C–N), and carbon-halogen (C–X) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the stand...
While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.
Combining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. • Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development • Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists • Organizes chapters by molecular structure of final products, making for a handbook-style resource • Discusses applications of the synthesis of natural products and of drug intermediates • Brings together otherwise-scattered information about a number of key, efficient chemical reactions
Ce roman vous entraîne dans le dur choix de l'éducation des enfants par les parents autrement dit soit la dispute verbale soit la fessée et c'est là tout le problème qui se pose, choisir l'un ou l'autre ou bien encore les deux. Au menu de ce roman sentimental, colère, rébellion, l'amour d'une mère pour son fils qui retient les leçons de vie. Tout à coup naît sa petite soeur et il s'en occupe avec amour fraternel, jouant au grand frère protecteur et tendre. Mais un jour, la maladie emporte la petite fille dans la mort. Leur fils déboussolé, ses parents trouveront-ils une solution après ce drame?
Seventeenth-Century Libraries: Problems and Perspectives presents key topics for understanding the theory and practice of library formation in the seventeenth century, both in Britain and on the Continent. In eight studies (plus a substantial introduction and afterword) based on meticulous research, the volume addresses questions of acquisition, classification, administration and access, spatial arrangement and furniture, networks of collecting, and dispersal of libraries, and serves as an introduction to methods of investigating these themes. Seventeenth-Century Libraries: Problems and Perspectives is a landmark volume that confronts outstanding issues of cultural and intellectual history by synthesizing recent research on the growth of libraries during a period that was crucial for the development of modern knowledge management, historical attitudes, and material culture. Contributors: Robyn Adams, Richard Foster, Francesca Galligan, Jaap Geraerts, Jacqueline Glomski, Shanti Graheli, Clodagh Murphy, David Pearson, Dominique Varry, and Elizabeth Wells.
Au Café des Délices, tous vos personnages préférés se retrouvent dans cette nouvelle aventure. Jonathan, qui a évolué professionnellement, va vivre une épreuve déstabilisante et très dangereuse. Il sait qu’il pourra toujours compter sur l’amour et le soutien de la petite famille du Café des Délices. La police enquête sur un meurtre étrange. Jonathan, anciennement flic à la BAC, reconverti en criminologue, va tout faire pour tenter de résoudre l’affaire la plus difficile et la plus éprouvante de toute sa carrière. Une course contre la montre va s’enclencher avec sa nouvelle coéquipière, l’intrigante et trépidante Lou. Pour traquer un tueur sans pitié et très minutieux, qui ne laisse aucune trace derrière lui. Jonathan va tenter d’entrer dans l’esprit de ce tueur, afin de prévoir ses prochaines victimes et pour essayer de les sauver. Y parviendra-t-il ? Saura-t-il déjouer ses pièges ?