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Presenting comprehensive and well-integrated coverage of physiology, pathophysiology, and clinical problems, Pediatric Critical Care Medicine is a core textbook and clinical reference for pediatric intensivists at all levels of training. It offers thorough preparation for subspecialty certification and recertification examinations and provides a ready reference for specific problems in the clinical setting. An extensive section on organ system physiology and pathophysiology provides the foundation for physiologically based clinical decision-making. Subsequent sections address clinical disorders of each organ system encountered in the pediatric ICU. The clinical chapters are concise and designed for rapid reference. Numerous illustrations and tables complement the text.
This new textbook is the definitive evidence-based resource for pediatric critical care. It is the first ostensibly evidence-based pediatric critical care textbook and will prove an invaluable resource for critical care professionals across the globe.
Provide the latest in superior quality care for critically ill children with the full-color, updated 4th Edition of Fuhrman and Zimmerman’s Pediatric Critical Care. In print, and now online, Drs. Bradley P. Fuhrman and Jerry J. Zimmerman use a comprehensive, organ-systems approach to help you manage a full range of disease entities. Get up-to-the-minute knowledge of topics such as acute lung injury, multiple organ dysfunction syndrome, and more. Implement new clinical techniques and diagnostic tests, weigh the varying perspectives of six associate editors with expertise in the field, reference 1,000+ illustrations to aid diagnosis, and keep sharp with online access to board-style review qu...
Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening in...
How a visionary university and foundation president tackled some of the thorniest problems facing higher education As provost and then president of Princeton University, William G. Bowen (1933–2016) took on the biggest and most complex challenges confronting higher education: cost disease, inclusion, affirmative action, college access, and college completion. Later, as president of the Andrew W. Mellon Foundation, he took his vision for higher education—and the strategies for accomplishing that vision—to a larger arena. Along the way, he wrote a series of influential books, including the widely read The Shape of the River (coauthored with Derek Bok), which documented the success of pol...
Features a joint medical-surgical approach, a problem orientation, and the use of case reports. Each chapter in this volume is devoted to a specific topic, and contains a general introduction to etiology, pathophysiology, and treatment. A medical problems list follows every case report, and listed with each problem is a further discussion of management strategies. A nursing care plan is also included. Provides coverage of special topics such as enteral nutrition, burns, toxic shock syndrome, coagulopathies, and pulmonary embolus, and more.
This groundbreaking and life-changing work based on the latest research effectively demonstrates “the profound impact that love, connection, and kindness have on our health” (Mark Williamson, PhD, director of Action for Happiness). When Columbia University doctor Kelli Harding began her clinical practice, she never intended to explore the invisible factors behind our health. But then there were the rabbits. In 1978, a seemingly straightforward experiment designed to establish the relationship between high blood cholesterol and heart health in rabbits discovered that kindness—in the form of a particularly nurturing post-doc who pet and spoke to the lab rabbits as she fed them—made the...
The guest editors have compiled expert authors to provide current updates on the clinical management of inborn errors of metabolism. Authors have contributed clinical review articles on the following topics: Inborn errors of metabolism overview: pathophysiology, manifestations, evaluation, and management; Inborn errors of metabolism with acidosis: organic acidemias and defects of pyruvate and ketone body metabolism; Inborn errors of metabolism with hyperammonemia: urea cycle defects and related disorders; Inborn errors of metabolism with hypoglycemia: glycogen storage diseases and gluconeogenesis defects; Inborn errors of metabolism with myopathy: defects of fatty acid oxidation and carnitin...
A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.