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Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds
The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans’ susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases. Screening of potential drugs from medicinal plants and animals provides a promising strategy for the alleviation of the impact of these diseases. Components with potential medicinal applications include RIPs, RNases, lectins, protease inhibitors and numerous small compounds. These compounds have shown both preventive and therapeutic effects for humans. This book is a compilation of articles written by internationally renowned experts exploring the different uses of medicinal compounds in human therapeutics. Here we provide a comprehensive outlook on both qualitative and quantitative studies focusing on medicinal plants and animals, and establishing a link between laboratory research discovery and clinical applications.
Towards a New 3Rs Era in Experimental Research
With the persisting need of animal experimentation for fundamental and applied research, the relevance and importance of the 3Rs Principle cannot be ignored. The 3Rs Principle was put forward over 50 years ago, providing an essential framework for more humane animal experimentation in research. In this half-century the research landscape within which this principle is applied has dramatically changed and evolved, with ever more emerging venues to explore for 3Rs advancement and implementation.
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications...
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Prowess, Piety, and Public Order in Medieval Society
Richard Kaeuper’s career has examined three salient concerns of medieval society - knightly prowess and violence, lay and religious piety, and public order and government - most directly in three of his monographs: War, Justice, and Public Order (Oxford, 1988), Chivalry and Violence in Medieval Europe (Oxford, 1999), and Holy Warriors (Penn, 2009). Kaeuper approaches historical questions with an eye towards illuminating the inherent complexities in human ideas and ideals, and he has worked to untangle the various threads holding together cultural constructs such as chivalry, licit violence, and lay piety. The present festschrift in his honor brings together scholars from across disciplines to engage with those same concerns in medieval society from a variety of perspectives. Contributors are: Bernard S. Bachrach, Elizabeth A.R. Brown, Samuel A. Claussen, David Crouch, Thomas Devaney, Paul Dingman, Daniel P. Franke, Richard Firth Green, Christopher Guyol, John D. Hosler, William Chester Jordan, Craig M. Nakashian, W. Mark Ormrod, Russell A. Peck, Anthony J. Pollard, Michael Prestwich, Sebastian Rider-Bezerra, Leah Shopkow, and Peter W. Sposato.
