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"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”
Internationally-recognized pain expert Don Goldenberg helps readers better understand the intricacies of chronic pain through the lens of personal stories, including his own. One out of three Americans lives with chronic pain. Pain is the number one reason we seek medical care and accounts for 40% of doctor visits. Chronic pain is the most common cause of work loss world-wide. The yearly cost of chronic pain in the United States is between $560-$630 billion, higher than that of heart disease, diabetes and cancer combined. Despite this, physicians and the public are woefully ill-informed about chronic pain. The litany of self-help books available to the public are largely misleading, quick-fi...
Over the last fifty years, many studies of psychiatric medication have been carried out on the basis of psychopharmacology. At the beginning, researchers and clinicians found the unexpected effectiveness of some medications with therapeutic effects in anti-mood without knowing the reason. Next, researchers and clinicians started to explore the mechanism of neurotransmitters and started to gain an understanding of how mental illness can be. Antidepressants are one of the most investigated medications. Having greater knowledge of psychopharmacology could help us to gain more understanding of treatments. In total ten chapters on various aspects of antidepressants were integrated into this book to help beginners interested in this field to understand depression.
‘Fascinating. Gomes provides a practical guide with an analysis of our mindset and the means to grow and strengthen it.’ The Financial Times ‘Each chapter angles the mirror to your face slightly differently, allowing you to pause, reflect and reposition your mindset to succeed.’ Will Page, author of Pivot and former Chief Economist of Spotify ‘Leading in a Non-linear World is a tour de force, drawing on the latest science of self-awareness to put forward clear-eyed, practical advice for how to live and lead in the 21st century.’ Stephen Fleming, Professor of Cognitive Neuroscience, University College London ‘A fabulous and provocative read from one of our most inspirational thi...
The Divergent Companion takes fans deeper into the post-apocalyptic Divergent world created by Veronica Roth: a dystopian Chicago in which society is split into five factions; each with its own core value to uphold. At the age of sixteen, like every other citizen, Beatrice Prior must choose to which faction she will devote her life . . . with devastating consequences. The Divergent Companion includes fascinating background facts, a revealing biography of the author, and amazing insights into the trilogy's major themes and features. A must have-read and a terrific gift for the millions of Divergent fans both young and old. This book is not authorized by Veronica Roth, Katherine Tegen Books, or anyone involved in the Divergent film.
Take Control of Your Life Chances are, you’ve already had run-ins with your Outer Child — the self-sabotaging, bungling, and impulsive part of your personality. This misguided, hidden nemesis blows your diet, overspends, and ruins your love life. Your Outer Child acts out and fulfills your legitimate childlike needs and wants in the wrong place, at the wrong time, and in counterproductive ways: It goes for immediate gratification and the quick fix in spite of your best-laid plans. Now, in a revolutionary rethinking of the link between emotion and behavior, veteran psychotherapist Susan Anderson offers a three-step program to tame your Outer Child’s destructive behavior. This dynamic, transformational set of strategies — action steps that act like physical therapy for the brain — calms your Inner Child, strengthens your Adult Self, releases you from the self-blame and shame at the root of Outer Child issues, and paves new neural pathways that can lead to more productive behavior. The result is happiness, fulfillment, self-mastery, and self-love.
The highly acclaimed comprehensive guide to getting your child through the formative pre-teen, teen, and college years drug-free—now completely revised and updated. Nearly every child will be offered drugs or alcohol before graduating high school, and excessive drinking is common at most colleges. But the good news is that a child who gets to age twenty-one without smoking, using illegal drugs, or abusing alcohol or prescription drugs is virtually certain never to do so. Drawing on more than two decades of research at The National Center on Addiction and Substance Abuse at Columbia University (CASAColumbia), founder Joseph A. Califano, Jr., presents a clear, common-sense guide to helping k...
The gold standard reference for all those who work with people with mental illness, Kaplan & Sadock's Comprehensive Textbook of Psychiatry, edited by Drs. Robert Boland and Marcia L. Verduin, has consistently kept pace with the rapid growth of research and knowledge in neural science, as well as biological and psychological science. This two-volume eleventh edition offers the expertise of more than 600 renowned contributors who cover the full range of psychiatry and mental health, including neural science, genetics, neuropsychiatry, psychopharmacology, and other key areas.