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Harnessing the Participation of Dendritic Cells in Immunity and Tolerance
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Epitope Discovery and Synthetic Vaccine Design
Since variolation, conventional approaches to vaccine development are based on live-attenuated, inactivated or purified pathogen-derived components. However, effective vaccines against global health threats such as HIV, parasite infections and tumors are difficult to achieve. On the other hand, synthetic vaccines based on immunogenic epitopes offer advantages over traditional vaccines since they are chemically defined antigens free from deleterious effects. Additionally, in contrast to live-attenuated vaccines, they do not revert to virulence in immunocompromised subjects, and different from genetic vaccines, they do not involve ethical questions. Traditional vaccines contain PAMPs and induc...
Handbook of Bioethical Decisions. Volume I
The Handbook of Bioethical Decisions is aimed at addressing and analyzing the most important ethical concerns and moral quandaries arisen in biomedical and scientific research. As such, it identifies and problematizes on a comprehensive range of ethical issues researchers must deal with in different critical contexts. Thus, the Handbook, Vol. I, may be helpful for them to make decisions and deliberate in complex practical scenarios. In this fashion, the volume reunites different points of view to give readers room enough to get a better knowledge and take their own position on pressing bioethical issues of the day. Consequently, this work seeks to engender dense ethical epistemology scientis...
COVID-19 and Sleep: A Global Outlook
This book examines the correlation of the coronavirus disease-19 [CE1] [AAS2] (COVID-19) infection with sleep, circadian rhythm, and sleep disorders. The chapters of the book explore sleep problems during the COVID-19 pandemic and its association with psychological distress and also review the prevalence of clinical cases of insomnia, anxiety, and depression in COVID-19 patients. The book further presents the correlation between sleep, circadian rhythms, and immunity that contributes toward more severe COVID-19. It summarizes the evidence on the interplay between circadian biology, sleep, and COVID-19. The chapters of the book discuss the relationship between obstructive sleep apnea (OSA) an...
Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity
The most efficient way to mount a sustained immune response is to target antigens to antigen presenting cells that trigger both innate and adaptive immune responses. A comprehensive view of the current approaches to the design of new antigenic formulations will enhance our understanding and perspective of targeted immunotherapy. The aim of this Research Topic is to provide an overview of the currently adopted targeting strategies by a collection of articles on: 1.Novel approaches of antigen targeting for immunotherapeutic strategies against cancer and/or infectious diseases. 2. Diversity and biology of dendritic cell subsets in human and mouse. 3. Combined strategies for the delivery of antigens and adjuvant molecules that stimulate innate immune responses and their influence on the quality of immune responses. 4. Impact of the receptor mediate intracellular trafficking on antigen presentation.
Métodos Alternativos ao Uso de Animais no Ensino
A perspectiva da necessidade da presente obra nasceu durante o I Simpósio de Métodos Alternativos, promovido pelo Conselho Nacional de Controle de Experimentação Animal (CONCEA) em setembro de 2016 na Universidade de São Paulo (USP). Na ocasião, diferentes docentes de cursos como Medicina, Medicina Veterinária e Ciências Biológicas apresentaram soluções criativas, inovadoras e éticas para a substituição do uso animal como recurso didático. Contudo, percebeu-se que a expressiva maioria se restringia a apresentar suas experiências em eventos científicos apenas. O percurso acadêmico de gerar a publicação de artigos e contribuir para formação de massa crítica técnica e ci...
A People's Church
A People's Church brings together a distinguished international group of historians to provide a sweeping introduction to Christian religious life and institutions in medieval Italy. Each essay treats a single theme as broadly as possible, highlighting both the unique aspects of medieval Christianity on the Italian peninsula and the beliefs and practices it shared with other Christian societies. Because of its long tradition of communal self-governance, Christianity in medieval Italy, perhaps more than anywhere else, was truly a "people's church." At the same time, its exceptional urban wealth and literacy rates, along with its rich and varied intellectual and artistic culture, led to divers...
Transforming REDD+
Constructive critique. This book provides a critical, evidence-based analysis of REDD+ implementation so far, without losing sight of the urgent need to reduce forest-based emissions to prevent catastrophic climate change. REDD+ as envisioned
