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Oncogenic PI3KT/Akt/mTOR Pathway Alterations, ROS Homeostasis, Targeted Cancer therapy and drug resistance
The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is an important signaling route that regulates several cell functions. PI3K/AKT/mTOR pathway is a crossroad of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and proliferation, apoptosis, and angiogenesis. Disruptions in the Akt‑regulated pathways and alterations in PTEN expression are associated to Reactive oxygen species (ROS) homeostasis and different types of cancer. Genomic studies have shown that activating mutations in oncogenes as well as inactivating mutations in tumor suppressor gen...
Physiology and Biochemistry of the Fishes of the Amazon
Biology and ecophysiology of fishes of the Amazon. Ecophysiological aspects of Amazonian blackwater litterbank fish communities. Electric signalling and communication in weakly electric fishes (Gymnotiformes) of South America. Reproductive biology of piranhas (Teleostei, Characiformes). Larval development in the tambaqui (Colossoma macropomum) and the curimatã-pacú (Prochilodus marggravii). Physiological responses to hypoxia and pH changes. Surviving low oxygen levels: Lessons from fishes of the Amazon. Hemoglobin adaptations in Amazonian and temperature fish with special reference to hypoxia, allosteric effectors and functional heterogeneity. Acid excretion in Amazonian fish. The interact...
Fisheries Review
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Biology of Tropical Fishes
Biology of tropical fish. The phosphagen system in vertebrate muscles: new insights. Detrended canonical correspondence analysis (DCCA) of electric fish assemblages in the Amazon. Mechanisms of signal analysis in Eigenmannia (Gymnotiformes): the jamming avoidance response and communication. Habitat abundance patterns of fish communities in three Amazonian rainforest streams. Recovery of an Amazonian blackwater fish fauna after extreme drought. The South American lungfish - adaptations to an extreme habitat. Management and diseases of the ornamental fish exported from the Rio Negro basin. Reproductive behaviour and ecology of two species of Cichlid fishes. Feeding habitats of nine cichlids found in Batata Lake (Porto Trombetas, PA, Brazil). Digestibility of seeds consumed by tambaqui (Colossoma macropomum Cuvier, 1818): an experimental approach. Effects of season and arousal state on the novelty response in Gymnotus carapo. Temperature and reproduction in Northern fish. Temperature and responsiveness of teleost melanophores...
Ciência E Cultura
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Oxidative Stress in Aquatic Ecosystems
Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.
