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Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmac...
NCRR Reporter
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Nonlinear Mixture Models: A Bayesian Approach
This book, written by two mathematicians from the University of Southern California, provides a broad introduction to the important subject of nonlinear mixture models from a Bayesian perspective. It contains background material, a brief description of Markov chain theory, as well as novel algorithms and their applications. It is self-contained and unified in presentation, which makes it ideal for use as an advanced textbook by graduate students and as a reference for independent researchers. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary background material needed to go further into the subject and...
Formal Modeling and Analysis of Timed Systems
This book constitutes the refereed proceedings of the 6th International Conference on Formal Modeling and Analysis of Timed Systems, FORMATS 2008, held in Saint Malo, France, September 2008. The 17 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 37 submissions. The papers are organized in topical sections on extensions of timed automata and semantics; timed games and logic; case studies; model-checking of probabilistic systems; verification and test; timed petri nets.
NIH Public Advisory Groups
Vols. for 1970- include Roster of members, formerly issued separately.
Pseudomonas
Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of n...
Modeling and Parameter Estimation in Respiratory Control
Experimentalists tend to revel in the complexity and multidimensionality of biological processes. Modelers, on the other hand, generally look towards parsimony as a guiding prin ciple in their approach to understanding physiological systems. It is therefore not surprising that a substantial degree of miscommunication and misunderstanding still exists between the two groups of truth-seekers. However, there have been numerous instances in physiology where the marriage of mathematical modeling and experimentation has led to powerful in sights into the mechanisms being studied. Respiratory control represents one area in which this kind of cross-pollination has proven particularly fruitful. While...
Bioengineering Approaches to Pulmonary Physiology and Medicine
As the current millennium steams towards a close, one cannot help but look with amazement at the incredible amount of progress that has been achieved in medicine in just the last few decades. A key contributing factor to this success has been the importation and blending of ideas and techniques from disciplines outside the traditional borders of medical science. In recent years, the most well-known example is the cross-pollination between molecular biology and medicine. Advances driven by this potent combination have spawned the vision of a future where cures based on gene therapy become commonplace. Yet, as we continue our search for "magic bullets" in the quest to eradicate disease, it imp...
