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Internationally recognized experts, pioneers, and opinion makers in evidence-based medicine (EBM) provocatively recast endocrine policy and practice in the light of EBM philosophy and principles. The authors explain the past, present, and future of EBM; consider its practical implications for endocrinology; demonstrate what the "evidence base" is in EBM; and present illustrative case studies by practicing evidence-based clinicians. Highlights include essays on why cost-effective analyses are problematic, the contrast between clinical investigations and large randomized trials, the role of Cochrane reviews and meta-analyses, and the curriculum requirements for training evidence-based endocrinologists.
A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
This book reviews novel developments in the endocrinology of hypertension with emphasis on new discovery during the past five years and perspectives on the future. It is written by authors who have spearheaded recent advances. With a focus on new developments in hormones and autacoids related to hypertension, the book provides a resource that will lead to new, active research in the fundamental mechanisms of hypertension.
This book covers the most important clinical and bench science aspects of metabolic syndrome. It will be of value to all of those seeking a comprehensive update on the metabolic syndrome. Furthermore, it will provide a broad basis for advancing research in the multiple intersecting disciplines encompassed by the metabolic syndrome.
The aim of this book is to inform clinicians of recent advances in obesity research and provide a review of current treatment issues and strategies. Part 1 covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Part 2 covers a range of issues that are central to the clinical management of obese patients. This illustrated volume will stimulate and engage clinicians.
Over the past few decades, cardiovascular disease and diabetes have emerged as major public health problems, both as distinct clinical entities and as comorbid conditions. As a result, the fields of vascular biology and endocrinology are working more closely now than ever before. With chapters by renowned experts, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads emphasizes the considerable physiological interrelationships and clinical correlations between the specialties of cardiovascular medicine and endocrinology. Offering a wealth of information, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads provides a range of insights, including a novel view ...
Here, the editor, Rogerio Lobo, has assembled an internationally recognized group of reproductive endocrinologists to address perimenopause -- the time both before and after the last menses -- and its attendant decline in ovarian function, as well as the clinical issues and therapeutic options for women during this period.
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This book focuses on precocious puberty, providing a unique continuum of expertise looking at puberty from anthropologic, epidemiologic, clinical, and molecular perspectives. The volume addresses broad pubertal changes in the general population while at the same time providing in depth information about specific disorders of puberty and the latest management changes. In particular, the book is intended for endocrinologists and internists.
Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.