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Oogenesis
The oocyte is the largest and most mysterious cell in the body of mammalian organisms. Through its growth and maturation, it reaches extreme levels of specialization, while maintaining at the same time a condition of totipotency. Its unique ability, in co-operation with the spermatozoon, to give rise to a fully developed organism formed from hundreds of different tissues and myriads of individual cells has inspired intellectuals of all ages. Oogenesis finds impetus and purpose in casting scientific perspective towards this unique cell for the benefit of scientists and assisted reproductive technology (ART) specialists. The authors of the chapters are distinguished authorities in their respective areas of competence. From the opening of the book the reader is lead on a fantastic voyage from the formation of the primordial oocyte to the development of the early embryo, passing through crucial processes of oogenesis, such as co-ordination of oocyte and follicle growth, gene expression and organelle reorganization during growth and maturation, epigenetic mechanisms, regulation of meiosis, totipotency, cell polarity, oogenesis in vitro and maternal regulation of early development.
Principles and Practice of Fertility Preservation
The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.
The Cytoskeleton
1 Mechanisms of Intracellular Organelle Transport.- 2 Organization and Function of Stress Fibers in Cells in Vitro and in Situ: A Review.- 3 The Form and Function of Actin: A Product of Its Unique Design.- 4 Changes in Actin during Cell Differentiation.- 5 The Dynamics of Cytoskeletal Organization in Areas of Cell Contact.- 6 Cell Shape and Membrane Receptor Dynamics: Modulation by the Cytoskeleton.- 7 The Biochemistry of Microtubules: A Review.- 8 MAP2 (Microtubule Associated Protein 2).- 9 Genetic Dissection of the Assembly of Microtubules and Their Role in Mitosis.- 10 Cytoskeleton in Plate.
Research Grants
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Environmental Chemistry
This title includes a number of Open Access chapters. Environmental chemistry is an interdisciplinary field of study that involves the science of ecology as well as chemistry. Environmental chemistry covers the basic chemistry and biochemistry that occur naturally in the world around us. It focuses on the air, water, and land. Environmental science normally begins by determining the chemical reactions that are occurring in the environment when all systems are in balance and then goes on the discover how chemistry has changed when there is an imbalance caused by stress or pollution. The field is constantly changing, with new discoveries being made all the time. The availability of new and more sensitive instruments in analytical science is enabling the detection of smaller and smaller concentrations of pollutants in the environment. This new volume deals with a host of important topics in environmental chemistry, such as pesticide-related illnesses in humans and plants, the effects of litterfall in the soil of tropical forests, toxicants in various bodies of water, and much more.
Manual of Embryo Selection in Human Assisted Reproduction
This manual will provide embryologists and clinicians with a clear, informative overview of the tools to assist in embryo selection.
Ovarian Cell Interactions
Due to the introduction of molecular and cellular biology approaches, our understanding of ovarian physiology has reached a new level during the last few years. The present volume provides a new perspective on the ovary from molecular and cellular to whole organ levels, from non-mammalian and rodent to human levels and from paracrine, neuroendocrine and endocrine levels as well. These papers represent the proceedings of the Ninth Ovarian Workshop sponsored by Serono Symposia, USA, July 9-11, 1992 in Chapel Hill, North Carolina.
