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The Chaperonins
The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. - Origins of the new view of protein folding - Prokaryotic chaperonins - Eukaryotic chaperonins - Evolution of the chaperonins - Refolding of denatured proteins - Organelle biosynthesis - Biomedical aspects
Metamorphosis
Metamorphosis addresses various facets of postembryonic development, particularly signal transduction, morphogenesis, cell-cell interactions, and programmed cell death. A key feature of the book is its exploration of the molecular mechanisms underlying these processes. - Hormonal regulation of development - The mechanisms of hormone action - The steroid/thyroid hormone receptor family - Morphogenesis and programmed cell death
Signal Transduction During Biomembrane Fusion
Signal Transduction during Biomembrane Fusion begins with three review articles that put the problem of signal transduction and biomembrane fusion into a general perspective. Each subsequent chapter begins with an introduction which reviews past work on a specific biological system. The authors' current research is then detailed. The chapters conclude with final comments wherein the contributors express viewpoints about the general significance and progression of their work. This book comprises 12 chapters, with the first focusing on signal transduction during biomembrane fusion. The succeeding chapters then discuss the ""focal membrane fusion"" model; osmotic phenomena in membrane fusion; c...
Nuclear Structure and Gene Expression
Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology
Pigment—Protein Complexes in Plastids
Pigment-Protein Complexes in Plastids: Synthesis and Assembly covers the different aspects of biosynthesis, assembly, and function of pigment-protein complexes. This book focuses on the molecular biology and physiological relevance of chlorophyll-protein complexes. The regulation and biosynthesis of chlorophyll proteins that involve a coordinated expression of nuclear and plastid genes and require communication among the cell organelles to respond properly to changing light and temperature conditions are also deliberated. This publication is intended for researchers in the fields of plant molecular biology, genetics, plant physiology and biochemistry, and cell biology, as well as students and teachers in agriculture, horticulture, biology, and biochemistry interested in pigment-protein complexes.
Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Three-Dimensional Confocal Microscopy: Volume Investigation of Biological Specimens
The integration of confocal microscopy and volume investigation has led to an unprecedented ability to examine spatial relationships between cellular structure and function. The goal of this book is to familiarize the reader with these new technologies and to demonstrate their applicability to a wide range of biological and clinical problems. - Volume investigation - Three-dimensional reconstruction - Fluroescent probe design - Biological applications of confocal microscopy, including calcium imaging, receptor movement, and diagnostic pathology - Confocal data display and analysis - Twenty-eight pages of color
Scientific Directory and Annual Bibliography
Each issue lists papers published during the preceding year.
