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Advances in Mechanisms of Renal Fibrosis
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
Immune Landscape of Kidney Pathology
Topic Editor Dr. Patrick Tang holds patents related to anticancer therapy and diabetic prevention. All other Topic Editors declare no competing interests with regards to the Research Topic.
Mitogen Activated Protein Kinases
Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.
In Situ Hybridization Protocols
The technique of in situ hybridization, in its various forms, has been used routinely in many laboratories for a number of years. In the post-genome era, gene arrays and proteomics have allowed us to identify hitherto unknown unrecognized pathways and mechanisms. However, rather than diminish the importance of in situ hybridization, the now widespread use of screening te- nologies has increased the need to temporally and spatially localize the dist- bution of mRNA expression. Our intention, in In Situ Hybridization Protocols is to provide ample inf- mation for novices planning to set up the in situ hybridization technique and use it in their laboratory for the first time, as well as giving u...
Mif: A Most Interesting Factor
In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.
Diseases of the Kidney and Urinary Tract
The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to evaluate and manage the disease process. Each of the fourteen sections is written by internationally renowned contributors and provides coverage comparable to a complete book. The first two sections review renal basic science and describe current diagnostic tools. The remaining twelve sections cover various types of diseases, including hypertension, urological problems, and urinary tract concerns. Each disease-oriented section begins with an up-to-date review of pathophysiology and then focuses on specific diseases. This edition has new lead authors for more than 25 chapters, and separate chapters on heart disease and the kidney, liver disease and the kidney, and the nephrotic syndrome.
IgA Nephropathy
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Molecular Medicine
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