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The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate...
As problems caused by environmental exploitation increase, related health issues are also becoming a major worldwide concern. Containing papers presented at the Third International Conference on the Impact of Environmental Factors on Health, this volume includes contributions from a variety of different disciplines and countries. The papers featured are divided into the following sections; Water Quality Issues; Air Pollution; Radiation Fields; Accident and Man-Made Risks; Risk Analysis; Emergency Response; Food Contamination; Electromagnetic Fields; Noise Pollution; Housing and Health; Occupational Health; Chemical Risk Assessment; Remediation; Social and Economic Issues; Education and Ecotoxicology Studies.
Microsomes and Drug Oxidations documents the proceedings of symposium on microsomes and drug oxidations held at Bethesda, Maryland, 16-17 February 1968. The theme of the symposium centered on the morphology of the liver endoplasmic reticulum, the localization of enzyme systems, the mechanisms for regulating enzyme activity, and the mechanisms of enzyme action. The results of this symposium presented in this book illustrate the complexity of the enzyme systems under investigation and the multiplicity of the variables altering their function. It is hoped the information presented will serve as a stimulus to other investigators in the elucidation of these problems. The book contains 27 papers organized into four parts. The papers in Part I examine the morphological and biochemical characteristics of microsomes. Part II presents studies on electron transfer components. Part III examines alterations of microsomal enzymes while Part IV focuses on drugs and protein synthesis.
Each year Americans take more than 300 million plane trips staffed by a total of some 70,000 flight attendants. The health and safety of these individuals are the focus of this volume from the Committee on Airliner Cabin Air Quality. The book examines such topics as cabin air quality, the health effects of reduced pressure and cosmic radiation, emergency procedures, regulations established by U.S. and foreign agencies, records on airline maintenance and operation procedures, and medical statistics on air travel. Numerous recommendations are presented, including a ban on smoking on all domestic commercial flights to lessen discomfort to passengers and crew, to eliminate the possibility of fire caused by cigarettes, and to bring the cabin air quality into line with established standards for other closed environments.
A timely and accessible synthesis of the strengths, weaknesses and reality of science through the eyes of a practicing scientist.
A CNN "Big story" entitled "Fire and smoke." Reporter Don Miller talks about the Ramstein air show disaster in West Germany, where reports of 67 spectators and 3 pilots were killed and hundreds more sustained injuries in the collision of three Italian jets. Italian officials say the Italian airshow team will continue to perform. Miller also discusses an airplane crash at the Dallas-Fort Worth airport of a Boeing 727 passenger jet resulting in 14 dead and another 76 injured. Concerned officials argue what steps should be taken to prevent recurrences of these kinds of disasters
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