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This advanced textbook on modeling, data analysis and numerical techniques for marine science has been developed from a course taught by the authors for many years at the Woods Hole Oceanographic Institute. The first part covers statistics: singular value decomposition, error propagation, least squares regression, principal component analysis, time series analysis and objective interpolation. The second part deals with modeling techniques: finite differences, stability analysis and optimization. The third part describes case studies of actual ocean models of ever increasing dimensionality and complexity, starting with zero-dimensional models and finishing with three-dimensional general circulation models. Throughout the book hands-on computational examples are introduced using the MATLAB programming language and the principles of scientific visualization are emphasised. Ideal as a textbook for advanced students of oceanography on courses in data analysis and numerical modeling, the book is also an invaluable resource for a broad range of scientists undertaking modeling in chemical, biological, geological and physical oceanography.
A mathematical mystery of calculations. The fearsome pirate Black Beard has buried his gold, and you have the map that leads the way. If you fail, you will be trapped inside the Cavern forever! Make your way through these thrilling adventure, using your math skills to decide how the plot unfolds. Complete your mission and become a math whiz at the same time! Finding the answers will enable readers to advance through an exciting adventure story.
Originally published as an e-book that became a controversial media phenomenon, No More Mr. Nice Guy! landed its author, a certified marriage and family therapist, on The O'Reilly Factor and the Rush Limbaugh radio show. Dr. Robert Glover has dubbed the "Nice Guy Syndrome" trying too hard to please others while neglecting one's own needs, thus causing unhappiness and resentfulness. It's no wonder that unfulfilled Nice Guys lash out in frustration at their loved ones, claims Dr. Glover. He explains how they can stop seeking approval and start getting what they want in life, by presenting the information and tools to help them ensure their needs are met, to express their emotions, to have a satisfying sex life, to embrace their masculinity and form meaningful relationships with other men, and to live up to their creative potential.
The information encoded in DNA is conveyed to the rest of the cell in a molecule called RNA. To diversify this information, as well as repair it when mistakes are made, RNA is modified through a series of reactions known as RNA editing. This book describes the fascinating and unexpectedly diverse ways RNA editing can occur, in organisms ranging from single- celled protozoa to man.
First multi-year cumulation covers six years: 1965-70.
'Big Machines' is a series for young children that shows big machines in action, explaining the tasks of their different features and how they work. Each book also includes a practical 'make it yourself' activity. This title looks at diggers.
GTPases are molecular switches that are used to control biochemical pathways. This book describes the properties and cellular roles of all the major families of GTPases. All cells use GTPases to regulate the delivery of amino acids to the ribosome during protein synthesis, but eukaryotes, with their complex and compartmentalized environment, have exploited the versatility of GTPases to a much greater extent. In particular, GTPases play a central role in regulating signal transduction pathways activated by extracellular signals and in regulating the trafficking of proteins beetween different organelles. It is not surprising, therefore, that GTPases have become a center of attention for those studying the control of proliferation, differentiation, cell polarity, cell movement, and vesicle and protein trafficking. This book provides a complete guide to this area and should be essential reading for cell and molecular biologists, biochemists and geneticists interested in these contemporary problems.
Since publication of the first edition in 1995, there have been significant advances and understanding of chromatin structure and its relation to gene expression. These include a high-resolution structure of the nucleosome core, discovery of the enzymes and complexes that mediate histone acetylation and deacetylation, discovery of novel ATP-dependent chromatin remodeling complexes, new insights into nuclear organization and epigenetic silencing mechanisms. In light of these advances, Chromatin Structure and Gene Expression (2ed.) includes updated chapters and additional material that introduce new concepts in the process of gene regulation in chromatin.
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy. They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokine receptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and tar...
Discover an exhilarating world of learning by solving a series of mathematical problems. Finding the answers will enable readers to advance through an exciting adventure story.