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Understanding the Process of Aging
This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging covers the functions of nitric oxide and peroxynitrite in mitochondria integrates several views on the role of mitochondria in the development of apoptosis gives a quantitative analysis of mutations of mitochondrial DNA during human aging highlights mitochondrial free radical production i...
Effects of Alcohol Use on Immunity and Immune Responses
Alcohol use disorder (AUD) is a significant global health burden. Globally alcohol misuse is the fifth leading risk factor for premature death and disability, and accounts for ~3.3 million deaths annually. Chronic alcohol use deleteriously affects both normal behavior (e.g., depression, anxiety, and alcohol craving) and physiology (e.g., oxidative stress, intestinal hyperpermeability, immune dysfunction, and organ damage). Both heavy and binge drinking patterns alter immune frequencies, compromise immune cell function, resulting in increased morbidity and mortality. Alcohol misuse can damage barrier functions in vital organs such as the lungs, gut, increase susceptibility to both bacterial a...
Etiology and Treatment of Acute Lung Injury
This book contains contributions of internationally known basic scientists and clinicians with expertise in various aspects of lung injury and repair. This monogram on the pathophysiology and treatment of Acute Lung Injury contains five different sections, each one with contributions from both basic and clinical scientists, outlining existing controversies, an how they can be resolved by future multidisciplinary studies. The various sections discuss: sodium transport and fluid clearance across the normal and injured lungs, the role of the pulmonary surfactant in the pathogenesis and treatment of ARDS, mechanisms and modification of acute and chronic lung injury, ventilatory strategies for the management of acute respiratory distress syndrome and nitric oxide: friend or foe.
Aequanimitas
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