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The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laborator...
The challenges we face these days are so great that we cannot rely entirely on ourselves, our communities, or our organizations to support us and help us stay on track. We need a small group of people with whom we can have in-depth discussions and share intimately about the most important things in our lives—our happiness and sadness, our hopes and fears, our beliefs and convictions. For the past thirty-five years, Bill George and Doug Baker have found the answer in what they call True North Groups. “At various times,” George and Baker write, “a True North Group will function as a nurturer, a grounding rod, a truth teller, and a mirror. At other times the group functions as a challen...
As the values of integrative medicine continues to grow, alternative points of view and treatments are increasing in acceptance and prevalence. Homeopathic medicine is considered an important root to this approach. However, contributions of homeopathically qualified doctors have long been overlooked. A Century of Homeopaths is a detailed account of the many homeopaths who have contributed to medical progress since 1840. The accomplishments of over 100 homeopaths form the organizing structure of the book - many of whom have been lost to history. The text describes the ways in which homeopaths have influenced medical practice, research and public health, as well as the seminal effect of homeopaths in the emergence of today's medical specialties and in social reform, thus providing insights to healthcare professionals, researchers, students and medical historians.
Feeley's English Homophone Dictionary is a specialized resource. Homophones are a particular feature of spoken and written English, words that have the same sound but different meanings and may have different roots and different spellings. This dictionary features... • a brief definition of the word • a pronunciation guide • identifies parts of speech • covers from early modern English to the present • provides examples of usage with references to the original • word category Clear and correct use of words is fundamental to good communication and Feeley's English Homophone Dictionary is a significant aid to doing so.
The first invasive evaluation of cardiac arrhythmias in humans was performed in 1967 in Paris (Prof. P. Coumel) and Amsterdam (Prof. D. Durrer). This was the start of a rapid increase in our knowledge of the diagnosis, mechanism and treatment of cardiac arrhythmias. In that same year Prof. Hein J.J. Wellens became cardiologist in the Wilhelmina Gasthuis in Amsterdam. Initially in Amsterdam (1967-1977) and later on in Maastricht (from 1977), he was the driving force for many breakthroughs in clinical cardiac electrophysiology. With an active interplay between the knowledge derived from the 12-lead electrocardiogram and the recordings made with invasive electrophysiology, he composed new ideas...
A collection of the short biographical profiles that have appeared monthly in the journal Clinical Cardiology from 1986 up to the present. The persons who are the subjects of these profiles are individuals who have contributed in a meaningful or unique way to knowledge in the field of cardiology.
In 1998 Professor Haïssaguerre and his colleagues made the initial observation in patients that triggering foci in or around the pulmonary veins initiate some types of atrial fibrillation. Since then it has become clear that atrial fibrillation and other atrial tachyarrhythmias can be initiated (and possibly maintained) by triggering foci in any of the thoracic veins. This concept is now one of the most current topics in electrophysiology, and while it is a topic of frequent discussion in the major cardiology and electrophysiology journals, Thoracic Vein Arrhythmias: Mechanisms and Treatment is the first state-of-the art multi-authored textbook that integrates the advances made in this rapi...