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While serendipity and random screening continue to fulfil a significant role in the search for new drugs, current remarkable advances in molecular biology and genetics are dictating to a profound extent the approaches employed in their development. Increasing attention is being devoted to investigations of the mechanisms of action of existing drugs, and the sources of undesired side effects, at the molecular level. The information so derived is now extensively applied, with the aid of broad inter disciplinary approaches, both theoretical and experimental, to improvements in existing drugs, and the rational design of new ones. The foregoing comprised the subject matter of the 3rd Inter nation...
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First book about key Soviet spy and Canadian communist. Fred Rose was deeply involved in atomic espionage.
Highlights of the volume include pioneering essays on the methodology of intelligence studies by Michael Fry and Miles Hochstein, and the future perils of the surveillance state by James Der Derian. Two leading authorities on the history of Soviet/Russian intelligence, Christopher Andrew and Oleg Gordievsky, contribute essays on the final days of the KGB. Also, the mythology surrounding the life of Second World War intelligence chief, Sir William Stephenson, The Man Called Intrepid', is penetrated in a persuasive revisionist account by Timothy Naftali. The collection is rounded off by a series of essays devoted to unearthing the history of the Canadian intelligence service.
The Second World War, with its emphasis on innovative weapons and defence technology, brought about massive changes in the role of scientists in Canada, the United States, and Great Britain. Canadian scientists, working through the auspices of the National Research Council and the Department of National Defence, made important contributions to the development of alliance warfare. Before 1939, Canada had only a minute military establishment and a limited industrial and academic capacity for research and development. With the outbreak of war, all this changed dramatically. This book explains how and why Canada was able to play in the big leagues of military technology, including the developmen...
Progress in Nucleic Acid Research and Molecular Biology
In the first major study of postwar social movement organizations in Canada, Dominique Clément provides a history of the human rights movement as seen through the eyes of two generations of activists. Drawing on newly acquired archival sources, extensive interviews, and materials released through access to information applications, Clément explores the history of four organizations that emerged in the sixties and evolved into powerful lobbies for human rights despite bitter internal disputes and intense rivalries. This book offers a unique perspective on infamous human rights controversies and argues that the idea of human rights has historically been highly statist while grassroots activism has been at the heart of the most profound human rights advances.
The battle against climate change is no longer just an environmental or social issue. As shareholders demand corporations protect assets against climate change and the economic impact of environmental disasters suck billions of dollars out of the economy, capitalism itself has become an ally. The economic impact of climate change is rattling the foundation of our economy at its very core. It’s blowing up centuries-old industries from automobiles to oil and gas, creating new opportunities for investors and entrepreneurs. It’s costing Americans billions of dollars each and every year. And most importantly, it’s forcing politicians to pass long-overdue policies that will transform our bus...
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The extraordinary story of scientists in East and West combatting HIV A small group of scientists were doggedly working in the field of antiviral treatments when the AIDS epidemic struck. Faced with one of the grand challenges of modern biology of the twentieth century, scientists worked across the political divide of the Cold War to produce a new class of antivirals. Their molecules were developed by a Californian start-up together with teams of scientists at the Rega Institute of KU Leuven and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences in Prague. These molecules became the cornerstone of the blockbuster drugs now used to combat and prevent HIV. Cold War Triangle gives an insight into the human face of science as it recounts the extraordinary story of scientists in East and West who overcame ideological barriers and worked together for the benefit of humanity.