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Origin of Life
It seems likely that scientists will someday discover how life can emerge on habitable planets like the early Earth and Mars. In Origin of Life: What Everyone Needs to Know(R), David W. Deamer has written a comprehensive guide to the origin of life that is organized in three sections. The first section addresses questions such as: Where do the atoms of life come from? How old is Earth? What was the Earth like before life began? Where does water come from? After each question is answered, there is a follow-up: How do we know? This expands the horizon of the book, explaining how scientists reach conclusions and why we can trust these answers. The second section describes how certain organic mo...
Origin of Life
It seems likely that scientists will someday discover how life can emerge on habitable planets like the early Earth and Mars. In Origin of Life: What Everyone Needs to Know®, David W. Deamer has written a comprehensive guide to the origin of life that is organized in three sections. The first section addresses questions such as: Where do the atoms of life come from? How old is Earth? What was the Earth like before life began? Where does water come from? After each question is answered, there is a follow-up: How do we know? This expands the horizon of the book, explaining how scientists reach conclusions and why we can trust these answers. The second section describes how certain organic mol...
Assembling Life
Explores the possibilities of how life began on Earth four billion years ago
First Life
"The origin of life may have happened an inconceivably long time ago, but scientists like David Deamer are making major advances in understanding how the first microbes began to seethe on our planet, ultimately giving rise to all species alive today. In First Life, Deamer offers a delightful synthesis of research into life's dawn with his own vision for how it came to be."—Carl Zimmer, author of The Tangled Bank: An Introduction to Evolution "No living scientist has had a greater impact on our understanding of life’s origins than Dave Deamer. In First Life, his remarkably engaging, constantly lucid, and delightfully personal narrative, Deamer takes us behind the scenes of origins researc...
The Origins of Life
Life arose on Earth more than three billion years ago. How the first self-replicating systems emerged from prebiotic chemistry and evolved into primitive cell-like entities is an area of intense research, spanning molecular and cellular biology, organic chemistry, cosmology, geology, and atmospheric science. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive account of the environment of the early Earth and the mechanisms by which the organic molecules present may have self-assembled to form replicating material such as RNA and other polymers. The contributors examine the energetic requirements for this process...
The Hunt for FOXP5
Genetics professor Michelle Murphy loses her husband under mysterious circumstances and without warning, while their brilliant eight year old daughter Avalon, adopted in Kazakhstan, stubbornly believes she is a mutant. As if this were not enough she soon finds herself thrown into the middle of a quickly thickening plot, where the legacy of Genghis Khan meets the hunt for FOXP5, a genetic transcription factor that could herald the dawn of new human species. Initially caught helplessly between well-meaning fellow scientists, the government and more sinister agents, Michelle, with the help of a host of unlikely heroes, eventually takes control and finds the courage to confront the decision of whether to save human lives or humanity. The scientific and technical aspects underlying the plot - in particular aspects of FOX proteins, genetic mutations, viruses and cancer as well as the relation between intelligence and cortical complexity - are introduced and discussed by the authors in an extensive non-technical appendix.
Nanopore Sequencing: An Introduction
This is an introductory text and laboratory manual to be used primarily in undergraduate courses. It is also useful for graduate students and research scientists who require an introduction to the theory and methods of nanopore sequencing. The book has clear explanations of the principles of this emerging technology, together with instructional material written by experts that describes how to use a MinION nanopore instrument for sequencing in research or the classroom.At Harvard University the book serves as a textbook and lab manual for a university laboratory course designed to intensify the intellectual experience of incoming undergraduates while exploring biology as a field of concentra...
Membrane Permeability: 100 Years Since Ernest Overton
Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs. Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern conce...
Origins of Life
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Structure and Dynamics of Confined Polymers
Polymers are essential to biology because they can have enough stable degrees of freedom to store the molecular code of heredity and to express the sequences needed to manufacture new molecules. Through these they perform or control virtually every function in life. Although some biopolymers are created and spend their entire career in the relatively large free space inside cells or organelles, many biopolymers must migrate through a narrow passageway to get to their targeted destination. This suggests the questions: How does confining a polymer affect its behavior and function? What does that tell us about the interactions between the monomers that comprise the polymer and the molecules tha...
