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Bacterial Exotoxins: How Bacteria Fight the Immune System
Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II mole...
Microbial Evolution and Co-Adaptation
Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.
Francisella tularensis and tularemia
The bacterium today known as Francisella tularensis was first identified 99 years ago and, since then, much research has been devoted to study it and the resulting disease, tularemia. F. tularensis became the focus of an intense research effort during the first half of the 20th century, in particularly in the United States and Soviet Union, since the disease was fairly common. Due to its high infectivity, ease of spread, and severity of the resulting disease, it was one of the agents given the highest priority in the biological weapon programs of the United States and Soviet Union. After termination of these programs in the 1960s, the interest in F. tularensis diminished significantly, but a...
Dissecting the Interactions Between Francisella Tularensis and Its Murine Host
Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adap...
When Hell Came to Sharpsburg
Discover a forgotten chapter of American history with Steven Cowie's riveting account of the Battle of Antietam. The Battle of Antietam, fought in and around Sharpsburg, Maryland, on September 17, 1862, was the bloodiest day in American history. Despite the large number of books and articles on the subject, the battle’s horrendous toll on area civilians is rarely discussed. When Hell Came to Sharpsburg: The Battle of Antietam and Its Impact on the Civilians Who Called It Home by Steven Cowie rectifies this oversight. By the time the battle ended about dusk that day, more than 23,000 men had been killed, wounded, or captured in just a dozen hours of combat—a grim statistic that tells only...
Constructing the Outbreak
When an epidemic strikes, media outlets are central to how an outbreak is framed and understood. While reporters construct stories intended to inform the public and convey essential information from doctors and politicians, news narratives also serve as historical records, capturing sentiments, responses, and fears throughout the course of the epidemic. Constructing the Outbreak demonstrates how news reporting on epidemics communicates more than just information about pathogens; rather, prejudices, political agendas, religious beliefs, and theories of disease also shape the message. Analyzing seven epidemics spanning more than two hundred years—from Boston's smallpox epidemic and Philadelp...
Characterization of Listeria Monocytogenes Growth and Colonization of the Murine Gallbladder
Listeria monocytogenes is a facultative intracellular pathogen that causes severe invasive disease in susceptible populations. Using in vivo bioluminescent imaging, it was recently discovered that this bacterium can colonize the murine gallbladder of otherwise asymptomatic mice. This finding was surprising as L. monocytogenes, after invasion of the intestines, was thought to survive only intracellularly in an infected host and in the gallbladder the bacteria lived extracellularly. It was also surprising that a bacterium could grow and replicate in the pure bile environment of the gallbladder lumen as bile is a potent antimicrobial compound. In this study, we characterized how Listeria monocy...
