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Exploration and Analysis of DNA Microarray and Protein Array Data
A cutting-edge guide to the analysis of DNA microarray data Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug’s therapeutic value–or toxicity–and cancer-spreading patterns of gene activity. Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in bo...
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R
This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restr...
Exploration and Analysis of DNA Microarray and Other High-Dimensional Data
Praise for the First Edition “...extremely well written...a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preproc...
The Practice of Data Analysis
This collection of essays brings together many of the world's most distinguished statisticians to discuss a wide array of the most important recent developments in data analysis. The book honors John W. Tukey, one of the most influential statisticians of the twentieth century, on the occasion of his eightieth birthday. Contributors, some of them Tukey's former students, use his general theoretical work and his specific contributions to Exploratory Data Analysis as the point of departure for their papers. They cover topics from "pure" data analysis, such as gaussianizing transformations and regression estimates, and from "applied" subjects, such as the best way to rank the abilities of chess ...
Biopharmaceutical Applied Statistics Symposium
This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights...
Applied Statistics in the Pharmaceutical Industry
Providing a general guide to statistical methods used in the pharmaceutical industry, and illustrating how to use S-PLUS to implement these methods, the book explains why S-PLUS is a useful software package and discusses the results and implications of each particular application. It is targeted at graduates in biostatistics, statisticians involved in the industry as research scientists, regulators, academics, and/or consultants who want to know more about how to use S-PLUS and learn about other sub-fields within the industry, as well as statisticians in other fields who want to know more about statistical applications in the pharmaceutical industry.
Statistics in Genetics and in the Environmental Sciences
Statistics is strongly tied to applications in different scientific disciplines, and the most challenging statistical problems arise from problems in the sciences. In fact, the most innovative statistical research flows from the needs of applications in diverse settings. This volume is a testimony to the crucial role that statistics plays in scientific disciplines such as genetics and environmental sciences, among others. The articles in this volume range from human and agricultural genetic DNA research to carcinogens and chemical concentrations in the environment and to space debris and atmospheric chemistry. Also included are some articles on statistical methods which are sufficiently gene...
Computational Statistical Methodologies and Modeling for Artificial Intelligence
This book covers computational statistics-based approaches for Artificial Intelligence. The aim of this book is to provide comprehensive coverage of the fundamentals through the applications of the different kinds of mathematical modelling and statistical techniques and describing their applications in different Artificial Intelligence systems. The primary users of this book will include researchers, academicians, postgraduate students, and specialists in the areas of data science, mathematical modelling, and Artificial Intelligence. It will also serve as a valuable resource for many others in the fields of electrical, computer, and optical engineering. The key features of this book are: Pre...
Biomedical Engineering
Biomedical Engineering: Health Care Systems, Technology and Techniques is an edited volume with contributions from world experts. It provides readers with unique contributions related to current research and future healthcare systems. Practitioners and researchers focused on computer science, bioinformatics, engineering and medicine will find this book a valuable reference.
Statistical Consulting
This book is intended for the statistician or student interested in becoming a statistical consultant, as well as clients who need to understand what is involved in the consulting process. It discusses different consulting environments, provides detailed descriptions of communication skills a consultant must possess, and provides concrete examples and case-studies of varying complexity. Emphasis is placed on the importance of engaging the client's understanding of the purpose and interpretation of statistical procedures.
