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Signalling Pathways in Apoptosis
Apoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility to cancer and sustained viral infection. Apoptosis is a matter of balance Dramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowledge bases being established is on the molecular mechanisms controlled by a variety of gene products including Bcl-2, caspases, death receptors, and proteolytic targets, as well as the central role of the mitochondrion. The major challenge in apoptosis research is how the protein products involved operate in an intricate web of signaling pathways that also play a crucial role in cell proliferation and differentiation. This book concentrates on elucidating these signal transduction mechanisms, an area not properly reviewed by other apoptosis texts.
The Making of the Modern British Home
The Making of the Modern British Home explores the impact of the modern suburban semi-detached house on British family life during the 1920s and 1930s - focusing primarily on working-class households who moved from cramped inner-urban accommodation to new suburban council or owner-occupied housing estates. Migration to suburbia is shown to have initiated a dramatic transformation in lifestyles - from a `traditional' working-class mode of living, based around long-established tightly-knit urban communities, to a recognisably `modern' mode, centred around the home, the nuclear family, and building a better future for the next generation. This process had far-reaching impacts on family life, en...
Programmed Cell Death
Only recently have the cellular and molecular aspects of cell suicide (or perhaps euthanasia) been investigated. From a September 1992 symposium in Brisbane, 26 papers report advances in the biochemical mechanisms, DNA fragmentation, genetic regulation, and apoptosis in the immune system and in cancer. Annotation copyright by Book News, Inc., Portland, OR
Perth and Kinross
Perth and Kinross, at the geographical heart of Scotland, contains a wide diversity of buildings including the remains of a Roman line of forts and watch towers, carved stones erected by the warrior aristocracy of the sixth to ninth centuries, the inventive medieval Dunkeld Cathedral, and the island fortress of Lochleven Castle. Blair Castle's mid-eighteenth-century stucco work is unequalled in Scotland. A multitude of smaller country houses embrace a variety of styles, while Georgian and Victorian churches, many with superb stained glass, abound. Towns and villages range from Dunkeld, the epitome of a small Scottish burgh, to the Royal burgh of Perth. This is the tenth volume in the Buildings of Scotland series.
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Biographical Dictionary of ScottishWomen
This single-volume dictionary presents the lives ofindividual Scottish women from earliest times to the present. Drawing on newscholarship and a wide network of professional and amateur historians, itthrows light on the experience of women from every class and category inScotland and among the worldwide Scottish diaspora.The BiographicalDictionary of Scottish Women is written for the general reading public andfor students of Scottish history and society. It is scholarly in itsapproach to evidence and engaging in the manner of its presentation. Eachentry makes sense of its subject in narrative terms, telling a story ratherthan simply offering information. The book is as enjoyable to read as it iseasy and valuable to consult. It is a unique and important contribution tothe history of women and Scotland.The publisher acknowledges support fromthe Scottish Arts Council and the Scottish Executive Equalities Unit towardsthe publication of this title.
Building the Modern Church
Fifty years after the Second Vatican Council, architectural historian Robert Proctor examines the transformations in British Roman Catholic church architecture that took place in the two decades surrounding this crucial event. Inspired by new thinking in theology and changing practices of worship, and by a growing acceptance of modern art and architecture, architects designed radical new forms of church building in a campaign of new buildings for new urban contexts. A focussed study of mid-twentieth century church architecture, Building the Modern Church considers how architects and clergy constructed the image and reality of the Church as an institution through its buildings. The author exa...
Attitudes Aren't Free
Attitudes Aren't Free: Thinking Deeply About Diversity in the US Armed Services ISBN: 9780982018569 LCCN: LCCN2010282390 Published June 2010 by Air University Press.
Built from Below: British Architecture and the Vernacular
This book extends the concept of British vernacular architecture beyond its traditional base of pre-modern domestic and industrial architecture to embrace other buildings such as places of worship, villas, hospitals, suburban semis and post-war mass housing. Engaging with wider issues of social and cultural history, this book is of use to anyone with an interest in architectural history. Presented in an essentially chronological sequence, from the medieval to the post-war, diverse fresh viewpoints in the chapters of this book reinforce understanding of how building design emerges not just from individual agency, that is architects, but also from the collective traditions of society.
History of Scottish Architecture
At last - here is a single volume authoritative history of Scottish architecture. This compact yet comprehensive account combines factual description of the vast and fertile range of visual forms and key architects in each period with a wide-ranging analysis of their social, ideological and historical context. As Scotland has often been closely involved with new trends in western architecture, this book highlights the interaction of Scottish developments with broader European and international movements. From the beginnings of the Renaissance in the 15th century right up to the 1990s ,this much-needed survey covers the entire post-medieval story in one volume.
