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The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients.
This text includes recent literature on pineal research on reproduction, melatonin rhythm, carbohydrate metabolism and immunity.
Annotation This book constitutes the refereed proceedings of the 32nd International Colloquium on Automata, Languages and Programming, ICALP 2005, held in Lisbon, Portugal in July 2005. The 113 revised full papers presented together with abstracts of 5 invited talks were carefully reviewed and selected from 407 submissions. The papers address all current issues in theoretical computer science and are organized in topical sections on data structures, cryptography and complexity, cryptography and distributed systems, graph algorithms, security mechanisms, automata and formal languages, signature and message authentication, algorithmic game theory, automata and logic, computational algebra, cache-oblivious algorithms and algorithmic engineering, on-line algorithms, security protocols logic, random graphs, concurrency, encryption and related primitives, approximation algorithms, games, lower bounds, probability, algebraic computation and communication complexity, string matching and computational biology, quantum complexity, analysis and verification, geometry and load balancing, concrete complexity and codes, and model theory and model checking.
This Open Access volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50 years ribosomes are a major research topic. Our knowledge about ribosome biogenesis and function such as transcription, mRNA modification, and translation was the sine qua non for developing the powerful RNA-based vaccines against RNA-viruses causing the world-threatening Covid-19 pandemia. The chapters in this book are organized into six parts. Part One discusses a comparative survey about the unity and diversity of ribosome biogenesis in pro- and eukaryotic cells. Part Two deals with the genomic organization of eukaryotic rDNA and the role of ...
First multi-year cumulation covers six years: 1965-70.