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Drug Discovery in Africa
Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challe...
Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this...
Advances in Medical Imaging, Detection, and Diagnosis
Medical care is the most critical issue of our time and will be so for the foreseeable future. In this regard, the pace and sophistication of advances in medicine in the past two decades have been truly breathtaking. This has necessitated a growing need for comprehensive reference resources that highlight current issues in specific sectors of medicine. Keeping this in mind, each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various important topics in a focused area of medicine—all accomplished in a user-friendly yet interconnected format. This volume addresses advances in medical imaging, detection, and diagnostic technologies. Tec...
Elements, Principles and Corpuscles
In Elements, Principles and Particles, Antonio Clericuzio explores the relationships between chemistry and corpuscular philosophy in the age of the Scientific Revolution. Science historians have regarded chemistry and corpuscular philosophy as two distinct traditions. Clericuzio's view is that since the beginning of the 17th century atomism and chemistry were strictly connected. This is attested by Daniel Sennert and by many hitherto little-known French and English natural philosophers. They often combined a corpuscular theory of matter with Paracelsian chemical (and medical) doctrines. Boyle plays a central part in the present book: Clericuzio redefines Boyle's chemical views, by showing th...
The Maritime Provinces a Handbook for Travellers
Reprint of the original, first published in 1875.
