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This book provides an analysis of the current subdisciplines comprising the study of humoral immune response. The first chapter presents a detailed discussion regarding the experimental and conceptual studies conducted prior to the mid-1970s that have served as a valuable research framework for investigators interested in the process by which B cells are activated following their exposure to antigens. Other chapters focus on topics such as membrane-associated proteins with important functional roles during B cell activation and differentiation; thymus-independent and thymus-dependent activation; mechanisms operative during B-T cell interactions, including the role of B cells as antigen-presenting cells; and the importance of soluble mediators. Additional topics include the regulatory role of T cells during B cell repertoire expression, memory development, tolerance, and autoimmunity. T-Cell Dependent and Independent B-Cell Activation is an important history and reference resource for humoral immune response investigators, as well as advanced graduate and medical students.
Advances in Immunology
This book introduces differential geometry and cutting-edge findings from the discipline by incorporating both classical approaches and modern discrete differential geometry across all facets and applications, including graphics and imaging, physics and networks. With curvature as the centerpiece, the authors present the development of differential geometry, from curves to surfaces, thence to higher dimensional manifolds; and from smooth structures to metric spaces, weighted manifolds and complexes, and to images, meshes and networks. The first part of the book is a differential geometric study of curves and surfaces in the Euclidean space, enhanced while the second part deals with higher di...
A major compilation & presentation of amino & DNA sequences produced under the direction of Dr. Elvin A. Kabat, who received a National Medal of Science in 1991, for his "seminal contributions in the field of immunology". Contains new & expanded sections on T-cell reactors, §2-microglobulins, major histocompatibiltiy antigens, complement, thymopoietin, integrins, & post-gamma globulin. Covers 9,000 sequences, plus 3 indices: index of proteins, index of antibody specificities & index of references. Best seller!!
Tabulation and analysis of amino acid and nucleic acid sequences of precursors, v-regions, c-regions, j-chain, T-cell receptors for antigen, T-cell surface antigens, l-microglobulins, major histocompatibility antigens, thy-1, complement, c-reactive protein, thymopoietin, integrins, post-gamma globulin, -macroglobulins, and other related proteins.
This is a monograph on fixed point theory, covering the purely metric aspects of the theory–particularly results that do not depend on any algebraic structure of the underlying space. Traditionally, a large body of metric fixed point theory has been couched in a functional analytic framework. This aspect of the theory has been written about extensively. There are four classical fixed point theorems against which metric extensions are usually checked. These are, respectively, the Banach contraction mapping principal, Nadler’s well known set-valued extension of that theorem, the extension of Banach’s theorem to nonexpansive mappings, and Caristi’s theorem. These comparisons form a sign...
Volume I contains a long article by Misha Gromov based on his many years of involvement in this subject. It came from lectures delivered in Spring 2019 at IHES. There is some background given. Many topics in the field are presented, and many open problems are discussed. One intriguing point here is the crucial role played by two seemingly unrelated analytic means: index theory of Dirac operators and geometric measure theory.Very recently there have been some real breakthroughs in the field. Volume I has several survey articles written by people who were responsible for these results.For Volume II, many people in areas of mathematics and physics, whose work is somehow related to scalar curvature, were asked to write about this in any way they pleased. This gives rise to a wonderful collection of articles, some with very broad and historical views, others which discussed specific fascinating subjects.These two books give a rich and powerful view of one of geometry's very appealing sides.
Praise for the Series:"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."--Enzymologia"This book is strongly recommended for researchers, teachers, students, administrators - in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inlusion in the scientist's personal library."--Journal of Medicinal Chemistry"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."--Norman Gilman, Hoffmann-La Roche, Inc, in the JOURNAL OF PHARMACEUTICAL SCIENCESAdvances in Medicinal Chemistry continues to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Provides a detailed survey of therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit.
This work covers review articles and research articles related to the "Bioactive Drugs in Drug Discovery Design". It covers the synthesis and properties of bioactive molecules and enzymes, the role of membranes in drug activity and formulation.