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A collection of up-to-date methods and data available in neuroscience, addressing issues from the molecular to the cellular and systems level of analysis. This volume includes coverage of electrophysical recording, neuronal cell culture, and preparation of tissues for microscopy or analysis.
Transplantation into the Mammalian CNS
A superb source of reference reviews as well as a concise overview of the functional cross-talk between neurons and glial cells, this book also focuses on microglia and inflammation in the aging brain and in neurological disorders. The scientific spectrum covered by this book is of key interest, and is recognized by the scientific community as a major competitive area with critical implications for human health.
In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals. Neuroprotective Signal Transduction pr...
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The Adrenal Medulla, 1989-1991 offers a comprehensive review of the world literature on the adrenal medulla published during this period. The book emphasizes the role of the adrenal medulla in advancing our knowledge of neuroscience; for example, the Nobel Prize-winning technique of patch clamping has been applied to stimulus-secretion coupling in adrenal chromaffin cells. The book also discusses such topics as the ability to image the distribution of calcium within individual neural cells, the ability to measure individual packets of neurotransmitter as they are released from cells, and advances in the understanding of ionic channels, cell-to-cell interactions, cell proliferation, sympathoadrenal ontogeny, growth factors, enzymatic biosynthetic pathways, electron and proton transfer, and neural pathways. Topics covered in clinical medicine include recent progress in the transplantation of the adrenal medulla to the brain as a treatment for Parkinson's disease and the latest reports on pheochromocytoma. The Adrenal Medulla, 1989-1991 is an essential book for neurobiologists, neurochemists, experimental biologists, physiologists, cell biologists, and informed clinicians.
During the past several decades, much research effort has gone into the elucidation of the role of neuroendocrine systems as secretory and metabolic regulators of cells of a variety of organs and structures, including the testes, ovaries, adrenals, thyroid, pituitary gland, and mammary glands. However, the role of cells comprising such organs and structures in the modulation of neuroendocrine processes has received considerably less is generally less well appreciated. attention and Nonetheless, it is important that we understand the actions on neuroendocrine systems of substances that reach the brain by way of the vasculature, including hormones, cytokines, toxins, amino acids, drugs, and si...