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Model organisms in inflammation and cancer
A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.
Green Fluorescent Protein
Since the discovery of the gene for green fluorescent protein (GFP), derived from jellyfish, this protein that emits a green glow has initiated a revolution in molecular biosciences. With this tool, it is now possible to visualize nearly any protein of interest in any cell or tissue of any species. Since the publication of the first edition, there have been tremendously significant technological advances, including development of new mutant variants. Proteins are now available in yellow and blue, and Novel Fluorescent Proteins (NFPs) have expanded their utility in developing biosensors, biological markers, and other biological applications. This updated, expanded new edition places emphasis on the rise of NFPs, including new chapters on NFP properties with detailed protocols, applications of GFPs and NFPs in industry research, and biosensors. This book provides a solid theoretical framework, along with detailed, practical guidance on use of GFPs and NFPs with discussion of potential pitfalls. The expert contributors provide real examples in showing how to tailor GFP/NFP to specific systems, maximize expression, and enhance detection.
Innate Immunity
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to playa key role in stimulating the subsequent clonal response of adaptive immunity. Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic prin...
Science
Since Jan. 1901 the official proceedings and most of the papers of the American Association for the Advancement of Science have been included in Science.
Genetics and Molecular Biology of Entomopathogenic Fungi
Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions, This thematic volume focuses on the advances and the future potential of the rapidly growing field of entomopathogenic fungi. With a focus on the genetics and molecular biology behind the progress, techniques developed to study all aspects of these fungi will be highlighted, and topics will span from systematics of fungi to how a fungus infects an insect and how that insect responds. - Critically analyzes future directions for the study of clinical genetics - Written and edited by recognized leaders in the field - Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics
Embryos
In this highly illustrated atlas, a group of internationally known authors review the development and significance of Arabidopsis, Dictyostelium discoideum, sea urchin, nematode worm, mollusc, leech, Drosophila, fish, toad, chick, mouse and human.
The Growth and Development of Specialized Cells, Tissues, and Organs
Collects articles discussing the specialization of cells, the processes of differentiation that occur in plant and animal cells, and how artificial differentiation can be used and the ethical questions it raises.
Women and Medicine
The third edition of Women and Medicine provides a comprehensive and definitive history, from early riots in medical schools when women tried to enroll, to women finally overcoming obstacles, making medical breakthroughs and enjoying brilliant medical careers. Biographical chapters look at the lives and accomplishments of Elizabeth Blackwell, Janet Travell, Mary Putnam Jacobi, Rosalyn Yalow and Gerty Cory, Marie Curie and other Nobel Prize Winners, Rosalie Slaughter Morton, Sophia Jex-Blake, Elizabeth Garett Anderson, and numerous others pioneers. Not just a resource in the field of women's studies or for women seeking careers in medicine, this book is a fascinating read and is also appropriate for high school level students seeking report material. Women and Medicine is a necessary addition to the field of women's studies, a resource for women seeking careers in medicine and useful to all women who seek models who challenge the status quo. Photos.
Nature
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