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Peptide Transport and Delivery into the Central Nervous System
Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on...
Therapy of Parkinson's Disease
A comprehensive review of current tactics in the therapeutic management of Parkinson's disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The well-timed Third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsoni
Neural Transplants
The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow s...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Research Grants
None
Trail to the Palisades
This is the second in a 3-novel series featuring Dan Currie, a gambler turned business man in an 1870s gold mining town high in the Colorado Rockies. Currie had always considered himself a lucky man. He'd won a non-producing gold mine in a poker game and soon hit one of the biggest strikes in Colorado. He and his wife, Etta, now owned several mines, a bank, a hotel, and a large ranch with thousands of cattle. But Currie's luck had suddenly turned bad. A huge explosion tore his highest producing gold mine apart. His bank was robbed. One of his young cowboys was brutally murdered when rustlers hit his ranch. Currie was shot off a cliff and nearly drowned. And now, someone had hired Sam Gash, a dangerous professional assassin to murder him. Lightening fast with a gun, Gash was also known to kill from ambush on occasion. One thing was certain. When Gash and Currie met, someone would surely die.
Progress in Alzheimer’s and Parkinson’s Diseases
This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Co...
