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Natural Products
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Search User Interfaces
The truly world-wide reach of the Web has brought with it a new realisation of the enormous importance of usability and user interface design. In the last ten years, much has become understood about what works in search interfaces from a usability perspective, and what does not. Researchers and practitioners have developed a wide range of innovative interface ideas, but only the most broadly acceptable make their way into major web search engines. This book summarizes these developments, presenting the state of the art of search interface design, both in academic research and in deployment in commercial systems. Many books describe the algorithms behind search engines and information retrieval systems, but the unique focus of this book is specifically on the user interface. It will be welcomed by industry professionals who design systems that use search interfaces as well as graduate students and academic researchers who investigate information systems.
(Un)masking Bruno Schulz
Whatever critical scalpel one selects for dissecting the literary works of Bruno Schulz (1892-1942), there will always be a certain degree of textual resistance which cannot be broken. Or in other words, taking off one of Schulz’s many masks, one will probably never avoid the impression that a new mask has emerged. This book contributes to the three most typical critical strategies of reading Schulz’s works (combinations, fragmentations, reintegrations) – being fully aware, of course, of the relativity of each particular approach. In addition, the book sets out to explore all of Schulz’s creative output (i.e. his stories as well as his graphic, epistolary and even literary critical w...
Exploratory Search
As information becomes more ubiquitous and the demands that searchers have on search systems grow, there is a need to support search behaviors beyond simple lookup. Information seeking is the process or activity of attempting to obtain information in both human and technological contexts. Exploratory search describes an information-seeking problem context that is open-ended, persistent, and multifaceted, and information-seeking processes that are opportunistic, iterative, and multitactical. Exploratory searchers aim to solve complex problems and develop enhanced mental capacities. Exploratory search systems support this through symbiotic human-machine relationships that provide guidance in e...
Contemplative Social Research
Contemplative Social Research brings together research and insights from scholars throughout Europe and North America, and from a variety of social science disciplines. The book argues that contemplative-based inquiry is unique in recognizing the deep oneness of humanity, since it requires embodied awareness as well as openness to the transpersonal dimensions of the human experience. No single discipline can deal with such vitally important issues as climate change, growing social inequalities, or the social impact of new digital technologies. Consequently, the book argues that only a contemplative vision that pushes the boundaries between disciplines and cultures can extend and broaden the ...
The Death Book
Providing a forum for children to ask questions about death, this resource uses visual jokes and informal language to inspire frank discussion and thoughtful reflection. The author provides a wide range of unsentimental, disarming ways of talking about death with her signature comedic drawing style, making fantasies, fears, and realities of death accessible for her readers. Full-color illustrations.
Broadband Services
Access to the Internet is an increasing problem in many areas of the world. As the popularity and usefulness of the Internet increases on a daily basis, lack of access to the technology is putting many groups at a disadvantage in terms of better education, better jobs and even in terms of higher levels of civic participation. However, creating a network infrastructure to serve outlying communities and sectors of the population is not straight-forward. This book brings together all the aspects of the problem – technical, regulatory and economic - into one volume to provide a comprehensive resource. It describes the latest technological advances that allow cost-effective network infrastructu...
Waugh in Abyssinia
In 1935 Italy declared war on Abyssinia and Evelyn Waugh was sent to Addis Ababa to cover the conflict. His acerbic account of the intrigue and political machinations leading up to the crisis is coupled with amusing descriptions of the often bizarre and seldom straightforward life of a war correspondent rubbing shoulders with less-than-honest officials, Arab spies, pyjama-wearing radicals and disgruntled journalists. Witty, lucid and penetrating, Evelyn Waugh captures the dilemmas and complexities of a feudal society caught up in twentieth-century politics and confrontation.
Food Process Engineering and Technology
The past 30 years have seen the establishment of food engineering both as an academic discipline and as a profession. Combining scientific depth with practical usefulness, this book serves as a tool for graduate students as well as practicing food engineers, technologists and researchers looking for the latest information on transformation and preservation processes as well as process control and plant hygiene topics. - Strong emphasis on the relationship between engineering and product quality/safety - Links theory and practice - Considers topics in light of factors such as cost and environmental issues
