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Cell Death
One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BC...
Apoptosis
Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
Means to an End
One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of t...
Apoptosis
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Sustainable Urbanism
Written by the chair of the LEED-Neighborhood Development (LEED-ND) initiative, Sustainable Urbanism: Urban Design with Nature is both an urgent call to action and a comprehensive introduction to "sustainable urbanism"--the emerging and growing design reform movement that combines the creation and enhancement of walkable and diverse places with the need to build high-performance infrastructure and buildings. Providing a historic perspective on the standards and regulations that got us to where we are today in terms of urban lifestyle and attempts at reform, Douglas Farr makes a powerful case for sustainable urbanism, showing where we went wrong, and where we need to go. He then explains how ...
Foundations of Public Service
Designed to serve as a basic text for an introductory course in Public Administration, this innovative work provides students with an understanding of the basic management functions that are covered in all standard textbooks with two important differences. First, it is written to address the needs of both the experienced practitioner and the entry-level public servant. Case examples bridge the content-rich environment of practitioners with the basic principles of public administration sought by pre-service students. Second, the discussion of basic management practices is grounded in the political and ethical tensions inherent in the American constitutional form of governance. This reflects t...
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Immunology, a Synthesis
In this second, revised edition of a textbook, E.S. Golub joins forces with D.R. Green to provide an up-to-date synthesis of modern immunology, spanning the full range of molecular, cellular and clinical immunology. Continuing in the tradition of the first edition and of The Cellular Basis of the Immune Response, Golub and Green describe immunology as a process by using experimental design and by following the sequence of experiments that have led to the current state of knowledge in the field.
Immune Consequences of Trauma, Shock, and Sepsis
Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. The growing role of immunology in medicine opens new avenues to the under- standing of trauma and sepsis and will allow the design of novel therapeutic approaches.
The Routledge Handbook of Urban Ecology
The birds, animals, insects, trees and plants encountered by the majority of the world’s people are those that survive in, adapt to, or are introduced to, urban areas. Some of these organisms give great pleasure; others invade, colonise and occupy neglected and hidden areas such as derelict land and sewers. Urban areas have a high biodiversity and nature within cities provides many ecosystem services including cooling the urban area, reducing urban flood risk, filtering pollutants, supplying food, and providing accessible recreation. Yet, protecting urban nature faces competition from other urban land uses. The Handbook of Urban Ecology analyses this biodiversity and complexity and provide...
