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Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.
Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells – the body’s self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases’ role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including: Arthritic and neurological disorders Lung disease He...
K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
The two volume set LNCS 5358 and LNCS 5359 constitutes the refereed proceedings of the 4th International Symposium on Visual Computing, ISVC 2008, held in Las Vegas, NV, USA, in December 2008. The 102 revised full papers and 70 poster papers presented together with 56 full and 8 poster papers of 8 special tracks were carefully reviewed and selected from more than 340 submissions. The papers are organized in topical sections on computer graphics, visualization, shape/recognition, video analysis and event recognition, virtual reality, reconstruction, motion, face/gesture, and computer vision applications. The 8 additional special tracks address issues such as object recognition, real-time vision algorithm implementation and application, computational bioimaging and visualization, discrete and computational geometry, soft computing in image processing and computer vision, visualization and simulation on immersive display devices, analysis and visualization of biomedical visual data, as well as image analysis for remote sensing data.
Deals with numerical methods that have been employed to simulate nonlinear water waves. This book covers important applications, such as overturning waves, breaking waves, waves generated by landslides, freak waves, solitary waves, tsunamis, sloshing waves, interaction of extreme waves with beaches, and interaction with fixed structures.
The purpose of this book is to put together recent developments on sediment transport and morphological processes. There are twelve chapters in this book contributed by different authors who are currently involved in relevant research. First three chapters provide information on basic and advanced flow mechanisms including turbulence and movement of particles in water. Examples of computational procedures for sediment transport and morphological changes are given in the next five chapters. These include empirical predictions and numerical computations. Chapters nine and ten present some insights on environmental concerns with sediment transport. Last two contributions deal with two large-scale case studies related to changes in the transport and provenance of glacial marine sediments, and processes involving land slides.
This book covers fluid dynamics and fluvial processes, including basics applicable to open channel flow followed by turbulence characteristics related to sediment-laden flows. It presents well-balanced exposure of physical concepts, mathematical treatments, validation of the models/theories, and experimentations using modern electronic gadgets within the scope. In addition, it explores fluid motions, sediment-fluid interactions, erosion and scouring, sediment suspension and bed load transportation, image processing for particle dynamics, and various problems of applied fluid mechanics in natural sciences. Features: Gives comprehensive treatment on fluid dynamics and fluvial process from fund...