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Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
Immunobiology of Leishmaniasis
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Evolution in Pharmacology of Infectious Diseases: 2022
There have been tremendous advancements in the Pharmacology of Infectious Diseases in recent years. These recent advancements underline the importance of a multidisciplinary approach in the study of infectious diseases. In order to explore this fast-growing area, Frontiers is launching a new series of Research Topics focusing on the evolution of methods, processes, scientific breakthroughs and technology advances in the field of Pharmacology of Infectious Diseases. In this article collection, we seek contributions exploring the changing context, the recent advances, the challenges, and the emerging new perspectives within the field.
Rule of Law, Human Rights and Judicial Control of Power
Judicial control of public power ensures a guarantee of the rule of law. This book addresses the scope and limits of judicial control at the national level, i.e. the control of public authorities, and at the supranational level, i.e. the control of States. It explores the risk of judicial review leading to judicial activism that can threaten the principle of the separation of powers or the legitimate exercise of state powers. It analyzes how national and supranational legal systems have embodied certain mechanisms, such as the principles of reasonableness, proportionality, deference and margin of appreciation, as well as the horizontal effects of human rights that help to determine how far a...
Medicinal and Aromatic Plants of South America Vol. 2
This volume, as the seventh of the series Medicinal and Aromatic Plants of the World, deals with the medicinal and aromatic plant (MAPs) treasures of the so-called Southern Cone, the three southernmost countries (Argentina, Chile and Uruguay) of South America. Similarly to the previous volumes of the series, the main focus is to collect and provide information on major aspects of botany, traditional usage, chemistry, production / collection practices, trade and utilization of this specific group of plants. The contributors, who are recognized professionals and specialist of the domain, have collected and present state of the art information on 41 species. Most of these are not only of interest from the scientific point of view, but hold also a potential for the prospective utilization of the decreasing, occasionally overexploited / endangered medicinal plant resources of this huge continent. The book is expected to serve as a source of information also on some less known or less studied species. As such the volume is expected to support future research and public health professionals.
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