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Esta obra se debruça sobre o pensamento filosófico do professor e pesquisador mineiro João Maurício Adeodato, formado na Faculdade de Direito do Recife, que passou por diversas universidades do mundo. Autores de vários estados dialogam com suas ideias, desenvolvidas em mais de 40 anos de dedicação à vida acadêmica. A publicação do debate aberto sobre suas ideias relacionadas à filosofia, direito e retórica, sem receio de criticar o autor — ou de ser por ele criticado — e dessa maneira seguir os seus próprios ensinamentos, é uma homenagem ao intelectual, que completa 60 aos de idade. A ideia do livro coletivo começou a ser formatada em 2017, com a realização de um seminário em sua homenagem, quando da comemoração dos 190 anos da Faculdade de Direito do Recife e dos 70 anos da Universidade Federal de Pernambuco, sendo o professor Adeodato parte visceral da biografia de ambas instituições, pela profunda influência na vida de várias gerações de juristas e de todos com quem conviveu, através das aulas e dos seus textos.
Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary o...
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The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
The book reviews recent developments and research results on excavations and foundations found in and on soft soil deposits. It gives an overview of the material properties of soft soils and offers new foundation improvement techniques in road and railways. It also examines different types of foundations and stabilization methods. The book will serve both practicing and research engineers in the field of geotechnical engineering.
The fifth edition of Handbook of Local Anesthesia is a practical "how-to" guide, updated with the latest advances in science, technology, and pain control techniques. From basic concepts to specific injection techniques, from dosage charts to the proper care and handling of equipment, key information is brought to life with an all-new, full-color design. Written by Dr. Stanley F. Malamed, dentistry's leading expert on this topic, it's a valuable reference that will enhance your practice of local anesthesia. Book jacket.
The Bhagavad-Gita has the original Sanskrit Text with Roman Transliteration, and a lucid English Rendition. Concise and to the point commentaries of two hundred twenty seven selected key verses are provided. One hundred thirtythree verses are printed in red to enable the first-time readers to study these verses before delving deep into the vast ocean of transcendental knowledge. The teachings of saints and sages of major religious denominations as well as world leaders and scholars have been included. Quotations from the Vedas, Puranas, Upanisads, Smrtis, Ramayana, Mahabharata, Bhakti-sutras, Brahma-sutra, Yoga-sutra, as well as other major scriptures of the world such as the Bible, Dhammapad and Koran have been incorporated to underline the basic unity of all religious thoughts and to promote the universal brotherhood of mankind. Epilogue, references, Sanskrit transliteration and pro-nunciation guide, glossary and index are provided. A guide to meditation, beautiful pictures and Gita Calisa are included for daily sadhana.
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.